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Merck
CN

03-0210-00

SMC® Human pTau217 High Sensitivity Immunoassay Kit

Used for ultrasensitive quantification of Human pTau217 in human serum, plasma, and cerebrospinal fluid (CSF)

别名:

pTau217 Single Molecule Counting kit, pTau217 immunoassay kit, pTau217 ultra-sensitive immunoassay, phospho Tau 217 immunoassay kit

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NACRES:
NA.55
UNSPSC Code:
12161503
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Usage:
 kit sufficient for 96 wells
Compatibility:
for use with FemtoQuest™ and SMCxPRO® instruments

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description

0.49-3.91pg/mL, refer to CoA for lot-specific LLOQ

Quality Level

200

technique(s)

single molecule counting: suitable

input

serum
plasma (K2 EDTA)
cerebrospinal fluid (CSF)

UniProt accession no.

P10636

compatibility

for use with FemtoQuest™ and SMCxPRO® instruments

shipped in

wet ice

storage temp.

2-8°C

product line

SMC®

usage

 kit sufficient for 96 wells

species reactivity

human

相关类别

General description

pTau217 (phospho-Tau 217) refers to a phosphorylated form of the tau protein at serine 217. This specific phosphorylation event alters tau′s conformation and enhances its propensity to aggregate into neurofibrillary tangles, which are hallmarks of several neurodegenerative diseases. In healthy neurons, tau stabilizes microtubules and facilitates intracellular transport. However, when phosphorylated at S217, tau misfolds and forms toxic aggregates that disrupt microtubule stability and impair neuronal function. Elevated levels of phospho Tau 217 in cerebrospinal fluid (CSF) serve as a sensitive biomarker for Alzheimer′s disease and other tauopathies, correlating with disease progression and cognitive decline. Moreover, pTau217 plays a role in neuroinflammation by activating glial cells, which can exacerbate neuronal injury and promote further neurodegenerative processes.

Application

Alzheimer′s Disease / Aging / Nervous System / Neurodegenerative Diseases / Neuroscience

Features and Benefits

  • Highly Sensitive Detection: Precisely quantifies pTau217 at femtogram/mL levels in serum, plasma or CSF.
  • Enhanced Signal Resolution: Expanded dynamic range with improved signal-to-noise ratio ensures consistent and accurate assay results.
  • Intuitive Assay Format: Leverages a straightforward sandwich immunoassay design for high-sensitivity detection.
  • Automation Compatible: Engineered for compatibility with automated liquid handling systems to minimize manual tasks and improve laboratory efficiency.
  • Knowledgeable Technical Support: Backed by experienced field scientists and technical teams.

Packaging

96 well assay

Analysis Note

  • Sensitivity: LLOQ 1,950 fg/ml* (SMCxPRO® Instrument)
  • Standard Curve Range: 490-500,000 fg/mL
  • Intra-assay CV: <15%
  • Inter-assay CV: <20%
  • Linearity: Serum: 104% Plasma: 111% CSF: 111%
  • Recovery: Serum: 102% Plasma: 94% CSF: 86%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Other Notes

Although pTau217was detectable in mouse, rat, non-human primate (baboon), cow, and pig samples, the assay has not been verified for these species.

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

target_organs

Respiratory Tract

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation

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Protocol- 03-0210-00

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