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Merck
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03-0211-00

SMC® Human pTau231 High Sensitivity Immunoassay Kit

Used for ultrasensitive quantification of Human pTau231 in human serum, plasma, and cerebrospinal fluid (CSF)

别名:

SMC® Human pTau231 High Sensitivity Immunoassay Kit, pTau231 Single Molecule Counting kit, pTau231 immunoassay kit, pTau231 ultra-sensitive immunoassay, phospho Tau 231 immunoassay kit

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NACRES:
NA.55
UNSPSC Code:
12161503
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Usage:
 kit sufficient for 96 wells
Compatibility:
for use with FemtoQuest™ and SMCxPRO® instruments

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species reactivity

human

Quality Level

200

technique(s)

single molecule counting: suitable

input

serum
cerebrospinal fluid (CSF)
plasma (K2 EDTA)

UniProt accession no.

P10636

compatibility

for use with FemtoQuest™ and SMCxPRO® instruments

shipped in

wet ice

storage temp.

2-8°C

product line

SMC®

usage

 kit sufficient for 96 wells

相关类别

General description

pTau231 (phospho-Tau 231) refers to a phosphorylated form of the tau protein at threonine 231. This specific phosphorylation alters tau′s structure and enhances its tendency to aggregate into neurofibrillary tangles, which are characteristic features of various neurodegenerative diseases. In healthy neurons, tau stabilizes microtubules and supports axonal transport, facilitating effective communication between neurons. However, when phosphorylated at T231, tau misfolds and forms toxic aggregates that disrupt microtubule stability, impairing neuronal function and contributing to cell death. Elevated levels of pTau231 in cerebrospinal fluid (CSF) serve as a biomarker for Alzheimer′s disease and other tauopathies, correlating with disease severity and cognitive decline. Additionally, phospho Tau 231 can promote neuroinflammation by activating glial cells, which further exacerbates neuronal injury and accelerates disease progression.

Application

Alzheimer′s Disease / Aging / Nervous System / Neurodegenerative Diseases / Neuroscience

Features and Benefits

  • Highly Sensitive Detection: Accurately measures pTau231 at femtogram/mL concentrations in serum, plasma or CSF.
  • Enhanced Signal Resolution: Expanded dynamic range with improved signal-to-noise ratio ensures consistent and accurate assay results.
  • Intuitive Assay Format: Leverages a straightforward sandwich immunoassay design for high-sensitivity detection.
  • Automation Compatible: Designed to work seamlessly with automated liquid handling systems to reduceg manual efforts and enhance laboratory productivity.
  • Knowledgeable Technical Support: Supported by skilled field scientists and expert technical teams.

Packaging

96 well assay

Analysis Note

  • Sensitivity: LLOQ 1,950 fg/mL* (SMCxPRO® Instrument)
  • Standard Curve Range: 490-500,000 fg/mL
  • Intra-assay CV: <15%
  • Inter-assay CV: <20%
  • Linearity: Serum: 114% Plasma: 166% CSF: 105%
  • Recovery: Serum: 81% Plasma: 57% CSF: 96%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Other Notes

Although pTau231 was detectable in mouse, rat, non-human primate (baboon), cow, and pig samples, the assay has not been verified for these species.

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

target_organs

Respiratory Tract

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation

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Protocol- 03-0211-00

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