SMC^® Human IFNλ1 High Sensitivity Immunoassay Kit

Interferon lambda 1 (IFN-λ1), also known as IL-29, is a type of cytokine belonging to the Type III interferon family, which also includes IL-28A and IL-28B. These cytokines are recognized for their role in the immune response against viral infections and are structurally similar to members of the IL-10 family. IL-29 is primarily produced by dendritic cells and is involved in the modulation of antiviral activity, acting similarly to type I interferons, though it interacts with a distinct receptor complex. This cytokine is crucial for its antiviral properties, immune regulation, and potential therapeutic implications in managing viral infections and certain autoimmune disorders. The specific signaling through its receptor can activate various pathways leading to the induction of antiviral state and regulation of immune responses.

Inflammation & Immunology/Inflammatory Disease/Immune Response/Autoimmune Disease

96 well assay

• Sensitivity: LLOQ 260 fg/mL* (SMCxPRO^® Instrument)
• Standard Curve Range: 130-200,000 fg/mL
• Intra-assay CV: <15%
• Inter-assay CV: <20%
• Linearity: Serum: 115% Plasma: 109%
• Recovery: Serum: 85% Plasma: 95%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

IFNλ1 was not cross-reactive with non-human primate, rat, mouse, feline or canine samples.

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SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

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