04-1551
Anti-SMRT Antibody, clone 1SM-1E7
ascites fluid, clone 1SM-1E7, from mouse
别名:
CTG repeat protein 26, Silencing mediator of retinoic acid and thyroid hormone receptor, T3 receptor-associating factor, Thyroid-, retinoic-acid-receptor-associated corepressor, nuclear receptor co-repressor 2, silencing mediator for retinoid and thyroid
产品名称
Anti-SMRT Antibody, clone 1SM-1E7, ascites fluid, clone 1SM-1E7, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
1SM-1E7, monoclonal
species reactivity
mouse, rat, human
technique(s)
western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NCOR2(9612), TRAC(28755)
Analysis Note
Evaluated by Western Blot in human brain lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected SMRT on 10 µg of human brain lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected SMRT on 10 µg of human brain lysate.
Application
Use Anti-SMRT Antibody, clone 1SM-1E7 (Mouse Monoclonal Antibody) validated in WB to detect SMRT also known as CTG repeat protein 26, Silencing mediator of retinoic acid & thyroid hormone receptor.
Biochem/physiol Actions
This antibody recognizes SMRT.
General description
The Silencing mediator of retinoic acid & thyroid hormone receptor protein, commonly called the SMRT protein mediates the transcriptional repression of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription machinery. Consistent with this activity, this protein is known to form a large corepressor complex containing SIN3A/B and histone deacetylases HDAC1 and HDAC2. SMRT is also a component of the N-Cor repressor (nuclear receptor corepressor), a multi-subunit complex minimally composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. SMRT and nuclear receptor corepressor N-CoR are related transcriptional corepressors which contain two distinct domains capable of interacting with unliganded nuclear receptors to repress their basal transcriptional activity.
~ 275 kDa
Physical form
Unpurified mouse monoclonal IgG2aκ ascites with 0.05% sodium azide.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Praveen Rajendran et al.
Molecular cancer, 10, 68-68 (2011-06-01)
Histone deacetylase (HDAC) inhibitors are currently undergoing clinical evaluation as anti-cancer agents. Dietary constituents share certain properties of HDAC inhibitor drugs, including the ability to induce global histone acetylation, turn-on epigenetically-silenced genes, and trigger cell cycle arrest, apoptosis, or differentiation
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