04-282
抗磷酸化EGFR（Thr654）抗体（克隆3F2）
clone 3F2, Upstate®, from mouse
别名:
ERBB, ERBB1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
3F2, monoclonal
Species reactivity:
mouse, human, canine, rat
Application:
ELISA, IP, WB
Citations:
6
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3F2, monoclonal
species reactivity
mouse, human, canine, rat
manufacturer/tradename
Upstate®
technique(s)
ELISA: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pThr654)
Quality Level
Gene Information
dog ... Egfr(404306)
human ... EGFR(1956)
mouse ... Egfr(13649)
rat ... Egf(25313)
General description
180 kDa
Immunogen
KLH偶联的合成肽，包括人EGFR中Thr 654周围的氨基酸。
Application
使用经验证可用于ELISA、IP& WB的该抗磷酸化EGFR（Thr654）抗体（克隆3F2）检测抗磷酸化EGFR（Thr654）。
Biochem/physiol Actions
可识别苏氨654处酸磷酸化的EGFR。
Physical form
溶于含有0.09%叠氮化钠、PEG、蔗糖和50%甘油的 PBS的100 µg（0.1 mg/ml）小鼠单克隆IgG1抗体。
形式：纯化
Analysis Note
对照
包括PMA 和过钒酸盐处理的Hep2G细胞裂解液作为阳性对照
包括PMA 和过钒酸盐处理的Hep2G细胞裂解液作为阳性对照
已通过免疫印迹进行常规评估。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane
Hunter, T, et al
Nature, 311, 480-483 null
Phosphorylation of Thr654 but not Thr669 within the juxtamembrane domain of the EGF receptor inhibits calmodulin binding
Aifa, Sami, et al
Biochemical and biophysical research communications, 347, 381-387 (2006)
Elena Odintsova et al.
The Journal of biological chemistry, 288(36), 26323-26334 (2013-07-31)
Ligand-induced ubiquitylation of EGF receptor (EGFR) is an important regulatory mechanism that controls endocytic trafficking of the receptor and its signaling potential. Here we report that tetraspanin CD82/KAI1 specifically suppresses ubiquitylation of EGFR after stimulation with heparin-binding EGF or amphiregulin
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