04-486
Anti-RhoG Antibody, clone 1F3 B3 E5
clone 1F3 B3 E5, Upstate®, from mouse
别名:
ARHG, RHOG ras homolog gene family, member G (rho G), MGC125835, MGC125836
产品名称
Anti-RhoG Antibody, clone 1F3 B3 E5, clone 1F3 B3 E5, Upstate®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
1F3 B3 E5, monoclonal
species reactivity
mouse, rat, human
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RHOG(391)
Analysis Note
Routinely evaluated by western blot on NIH/3T3 cell lysate.
Application
Anti-RhoG Antibody, clone 1F3 B3 E5 is an antibody against RhoG for use in WB.
Biochem/physiol Actions
Recognizes RhoG
General description
21 kDa
RhoG (ARGH) is a member of the Ras super-family of small G-proteins and a member of the Rac subfamily of Rho Family of GTPases. RhoG is a small G-protein (GTPase) who is activated by a GEF (guanine nucleotide exchange factor). The GEF displaces GDP from the binding site of RhoG and allows GTP to bind in it place rendering the protein active. This active RhoG binds downstream effector molecules that include ELMO and DOCK180. RhoG then cleaves GTP to GDP making it inactive. RhoG is believed to be crucial for integrin-mediated Rac activation and cell spreading. RhoG is believed to be active upstream of Rac and work independently of Rac.
Immunogen
KLH synthetic peptide encompassing amino acids CQQDGVKEVFAEAVRAVLNPT (RhoG 160-180)
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Purified mouse monoclonal IgG2b in storage buffer containing PBS with 0.05% sodium azide.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.
Moshfegh, Y; Bravo-Cordero, JJ; Miskolci, V; Condeelis, J; Hodgson, L
Nature Cell Biology null
Aneta Kwiatkowska et al.
Molecular cancer, 11, 65-65 (2012-09-13)
The invasion of glioblastoma cells into regions of the normal brain is a critical factor that limits current therapies for malignant astrocytomas. Previous work has identified roles for the Rho family guanine nucleotide exchange factors Trio and Vav3 in glioblastoma
Sergi Marco et al.
Nature communications, 12(1), 6829-6829 (2021-11-26)
Signals are relayed from receptor tyrosine kinases (RTKs) at the cell surface to effector systems in the cytoplasm and nucleus, and coordination of this process is important for the execution of migratory phenotypes, such as cell scattering and invasion. The
Kristin Franke et al.
The EMBO journal, 31(13), 2908-2921 (2012-05-17)
The small GTPase RhoG plays a central role in actin remodelling during diverse biological processes such as neurite outgrowth, cell migration, phagocytosis of apoptotic cells, and the invasion of pathogenic bacteria. Although it is known that RhoG stimulates neurite outgrowth
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