04-967
Anti-Desert hedgehog protein (DHH) Antibody, clone 19D7.2
clone 19D7.2, from mouse
别名:
desert hedgehog homolog (Drosophila), desert hedgehog (Drosophila) homolog, desert hedgehog
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
19D7.2, monoclonal
种属反应性
rat, human
技术
immunohistochemistry: suitable
western blot: suitable
同位素/亚型
IgMκ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... DHH(50846)
一般描述
Desert Hedgehog (DHH) is one of three signaling molecules belonging to the hedgehog family, a group of intracellular signaling molecules characterized for their regulatory ability in developmental tissue patterning. DHH is an essential component to the integrity of peripheral nerve function and structure. There is also strong support that it is critical to normal, testicular development, and the survival of spermatocytes. DHH cleaves into two chains; the DHH N-product which is localized at the cell surface, and the DHH C-product which diffuses from the cell. Defects in expression are though to cause complete pure gonadal dysgenesis 46,XY type (GDXYM), and partial gonadal dysgenesis with minifascicular neuropathy 46, XY (PGD).
~ 44 kDa observed
免疫原
KLH-conjugated linear peptide corresponding to human Desert hedgehog protein.
应用
Detect Desert hedgehog protein (DHH) using this Anti-Desert hedgehog protein (DHH) Antibody, clone 19D7.2 validated for use in WB, IH.
Immunohistochemistry Analysis: 1:600 dilution from a previous lot detected Desert hedgehog protein in malignant teratoma tissue.
外形
Format: Purified
分析说明
Control
Rat spinal cord tissue lysate
Rat spinal cord tissue lysate
Evaluated by Western Blot in rat spinal cord tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Desert hedgehog protein on 10 µg of rat spinal cord tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Desert hedgehog protein on 10 µg of rat spinal cord tissue lysate.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ashish G Toshniwal et al.
Developmental cell, 49(3), 473-489 (2019-05-08)
Reactive oxygen species (ROS), despite having damaging roles, serve as signaling molecules regulating diverse biological and physiological processes. Employing in vivo genetic studies in Drosophila, we show that besides causing G1-S arrest by activation of Dacapo, ROS can simultaneously inhibit cell
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