04-967
Anti-Desert hedgehog protein (DHH) Antibody, clone 19D7.2
clone 19D7.2, from mouse
别名:
desert hedgehog homolog (Drosophila), desert hedgehog (Drosophila) homolog, desert hedgehog
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
19D7.2, monoclonal
Application:
IHC, WB
Citations:
1
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
19D7.2, monoclonal
species reactivity
rat, human
technique(s)
immunohistochemistry: suitable, western blot: suitable
isotype
IgMκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DHH(50846)
General description
Desert Hedgehog (DHH) is one of three signaling molecules belonging to the hedgehog family, a group of intracellular signaling molecules characterized for their regulatory ability in developmental tissue patterning. DHH is an essential component to the integrity of peripheral nerve function and structure. There is also strong support that it is critical to normal, testicular development, and the survival of spermatocytes. DHH cleaves into two chains; the DHH N-product which is localized at the cell surface, and the DHH C-product which diffuses from the cell. Defects in expression are though to cause complete pure gonadal dysgenesis 46,XY type (GDXYM), and partial gonadal dysgenesis with minifascicular neuropathy 46, XY (PGD).
~ 44 kDa observed
Immunogen
KLH-conjugated linear peptide corresponding to human Desert hedgehog protein.
Application
Detect Desert hedgehog protein (DHH) using this Anti-Desert hedgehog protein (DHH) Antibody, clone 19D7.2 validated for use in WB, IH.
Immunohistochemistry Analysis: 1:600 dilution from a previous lot detected Desert hedgehog protein in malignant teratoma tissue.
Physical form
Format: Purified
Analysis Note
Control
Rat spinal cord tissue lysate
Rat spinal cord tissue lysate
Evaluated by Western Blot in rat spinal cord tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Desert hedgehog protein on 10 µg of rat spinal cord tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Desert hedgehog protein on 10 µg of rat spinal cord tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Ashish G Toshniwal et al.
Developmental cell, 49(3), 473-489 (2019-05-08)
Reactive oxygen species (ROS), despite having damaging roles, serve as signaling molecules regulating diverse biological and physiological processes. Employing in vivo genetic studies in Drosophila, we show that besides causing G1-S arrest by activation of Dacapo, ROS can simultaneously inhibit cell
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