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Merck
CN

05-23-3800

内皮素1，人和猪

Endothelin 1, Human and Porcine, CAS 117399-94-7, is a 21-amino acid polypeptide with potent vasoconstrictive action. Activates phospholipase C in fibroblasts expressing ETA receptors.

别名:

内皮素1，人和猪, ET-1, PPET1, 前内皮素原-1

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关于此项目

经验公式（希尔记法）:
C109H159N25O32S5
化学文摘社编号:
117399-94-7
分子量:
2491.90
NACRES:
NA.77
UNSPSC Code:
12352202
MDL number:
MFCD00133305

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InChI

1S/C109H159N25O32S5/c1-12-56(9)87(107(163)125-76(109(165)166)39-60-43-113-65-24-18-17-23-63(60)65)134-108(164)88(57(10)13-2)133-99(155)75(42-85(143)144)123-94(150)70(36-54(5)6)118-97(153)73(40-61-44-112-52-114-61)121-103(159)80-49-169-168-48-64(111)89(145)126-77(45-135)102(158)131-81-50-170-171-51-82(105(161)132-86(55(7)8)106(162)124-72(38-59-26-28-62(138)29-27-59)95(151)120-71(96(152)130-80)37-58-21-15-14-16-22-58)129-91(147)67(30-31-83(139)140)116-90(146)66(25-19-20-33-110)115-98(154)74(41-84(141)142)122-92(148)68(32-34-167-11)117-93(149)69(35-53(3)4)119-100(156)78(46-136)127-101(157)79(47-137)128-104(81)160/h14-18,21-24,26-29,43-44,52-57,64,66-82,86-88,113,135-138H,12-13,19-20,25,30-42,45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,118,153)(H,119,156)(H,120,151)(H,121,159)(H,122,148)(H,123,150)(H,124,162)(H,125,163)(H,126,145)(H,127,157)(H,128,160)(H,129,147)(H,130,152)(H,131,158)(H,132,161)(H,133,155)(H,134,164)(H,139,140)(H,141,142)(H,143,144)(H,165,166)

InChI key

ZUBDGKVDJUIMQQ-UHFFFAOYSA-N

biological source

Porcine, human

assay

≥96% (HPLC)

form

solid

mol wt

2491.9 g/mol

manufacturer/tradename

Calbiochem®

storage condition

(Tightly closed Dry), OK to freeze, desiccated

technique(s)

cell culture | mammalian: suitable

color

white to off-white

solubility

5% acetic acid: 0.5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

General description

研究领域：细胞信号传导

内皮素1（ET-1）是一种位于内皮细胞的肽激素 ，属于内皮缩血管肽家族。它是前内皮素原1（pre-pro-ET-1）的衍生物，前内皮素原1在一组ET转化酶（ECE）肽、链内切酶、糜蛋白酶和非ECE金属蛋白酶的作用下转化为成熟ET-1 。EDN1基因定位于人染色体6p24.1。

Application

人和猪内皮素1 - CAS 117399-94-7 – Calbiochem可用于：
  • 研究其在大鼠模型中常氧和一氧化碳引起的缺氧条件下红细胞生成素生成中的作用
  • 作为蛋白质激酶C （PKC） 激动剂用于研究其在大鼠肌细胞中肌丝蛋白磷酸化的影响
  • 诱发类肥大状态以研究其在正常和变异人诱导多能干细胞（hiPSC）分化的心肌细胞中收缩压的影响。

Biochem/physiol Actions

内皮素1（ET-1）可作为旁分泌和自分泌功能的介导子。在ET-1 的生产在病理生理条件下上调，它也由多种细胞产生，如心肌细胞、血管平滑肌细胞以及炎症细胞，如白细胞和巨噬细胞。ET-1是一种强效的血管收缩肽，由心血管病中多种细胞的风险因子刺激。它参与许多生物效应，如促炎作用、血小板激活、自由基的刺激以及促有丝分裂和增生作用。ET-1在肺生理学、神经学功能、自身免疫性疾病、电解质和体液的运输以及癌症中起一定作用。它是源于胚胎神经嵴的组织发育的必要成分。ET-1 通过激活Wnt信号通路促进成骨细胞增殖，从而参与骨生成。

Packaging

是

Physical form

以醋酸盐形式提供。

Preparation Note

复溶后，等分并冷冻保存（-20°C）。储备液可在-20°C最长稳定2周。
最初将肽以8 mg/ml的浓度溶于80%的冷乙酸中，然后用蒸馏水稀释以达到5%的乙酸和0.5 mg/ml的肽。

Other Notes

Cesari, M., et al. 1996.Am. Heart J.132, 1236.
Gresser, O., et al 1996.Biochem.Biophys.Res. Commun.224, 169.
Murata, S., et al. 1995.J. Pharmacol.Exp.Ther.274, 1524.
Hexum, T.D., et al. 1990.Biochem.Biophys.Res. Commun.167, 294.
Itoh, Y., et al. 1988.FEBS Lett.231, 440.
Yanagisawa, M., et al. 1988.Nature 332, 411.
H-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH（二硫键：1 → 15; 3 → 11）

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：标准处理（A）

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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A Grenz et al.
Naunyn-Schmiedeberg's archives of pharmacology, 373(5), 342-348 (2006-08-10)
It has been hypothesized that autacoids, such as endothelin-1 (ET), may modulate erythropoietin (Epo) secretion. Therefore, we studied the effect of ET-1 infusion and of a nonselective ET(A/B) receptor antagonist on Epo secretion under carbon monoxide (CO) exposure. Anesthetized rats
Lisa R Stow et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(1), 16-28 (2010-09-15)
Over two decades of research have demonstrated that the peptide hormone endothelin-1 (ET-1) plays multiple, complex roles in cardiovascular, neural, pulmonary, reproductive, and renal physiology. Differential and tissue-specific production of ET-1 must be tightly regulated in order to preserve these
Gregory A Clines et al.
Molecular endocrinology (Baltimore, Md.), 21(2), 486-498 (2006-10-28)
Tumor-produced endothelin-1 (ET-1) stimulates osteoblasts to form new bone and is an important mediator of osteoblastic bone metastasis. The anabolic actions of ET-1 in osteoblasts were investigated by gene microarray analyses of murine neonatal calvarial organ cultures. Targets of ET-1
Indranil Chattopadhyay et al.
Mutation research, 696(2), 130-138 (2010-01-20)
Genomic alterations such as chromosomal amplifications, deletions and loss of heterozygosity play an important role in the pathogenesis and progression of cancer. Environmental risk factors contribute to the development and progression of tumors by facilitating the loss of tumor suppressor
Felix Böhm et al.
Cardiovascular research, 76(1), 8-18 (2007-07-10)
Endothelin (ET)-1 is a potent vasoconstrictor peptide originally isolated from endothelial cells. Its production is stimulated in a variety of different cell types under the influence of risk factors for cardiovascular disease and during the development of cardiovascular disease. Based
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