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Merck
CN

05-364

抗-Cdk5抗体，克隆DC17

clone DC17, Upstate®, from mouse

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
DC17, monoclonal
Application:
ICC, IP, WB
Citations:
30

主要文件

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biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

DC17, monoclonal

species reactivity

mouse, human, Drosophila, rat

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG1

NCBI accession no.

NP_004926

UniProt accession no.

Q00535

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

fruit fly ... Cdk5(36727)
human ... CDK5(1020)
mouse ... Cdk5(12568)
rat ... Cdk5(140908)

General description

33kDa

Immunogen

重组人cdk5

Application

抗-Cdk5 抗体（克隆 DC17）是用于检测Cdk5 的高质量小鼠单克隆抗体，&已在 IP、WB、ICC 中进行了验证。
研究子类别
细胞周期，DNA 复制&修复
研究类别
表观遗传学&核功能

Biochem/physiol Actions

cdk5

Physical form

0.1M Tris-甘氨酸（pH 7.4），0.15M NaCl，含0.05％叠氮化钠。
形式：纯化
蛋白G层析

Preparation Note

在-20°C下可保存2年

Analysis Note

对照
阳性抗原对照：货号12-301，未刺激的A431细胞裂解液。 加入2.5µL 2-巯基乙醇/100µL裂解液，煮沸5分钟以 减少制备量。在微凝胶每个泳道上样20µg经还原的裂解液。
通过免疫印迹对未刺激的人A431细胞、小鼠Wehi 细胞或大鼠PC12细胞的RIPA裂解液进行了常规评估

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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The presence of active Cdk5 associated with p35 in astrocytes and its important role in process elongation of scratched astrocyte.
Yi He,Hui-Li Li,Wei-Yan Xie,Chun-Zhang Yang,Albert Cheung Hoi Yu,Yun Wang
Glia null
K Sobue et al.
The Journal of biological chemistry, 275(22), 16673-16680 (2000-04-06)
Neuronal Cdc2-like protein kinase (NCLK), a approximately 58-kDa heterodimer, was isolated from neuronal microtubules (Ishiguro, K., Takamatsu, M., Tomizawa, K., Omori, A., Takahashi, M., Arioka, M., Uchida, T. and Imahori, K. (1992) J. Biol. Chem. 267, 10897-10901). The biochemical nature
Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus.
Yin, DM; Huang, YH; Zhu, YB; Wang, Y
The Journal of Neuroscience null
S R Floyd et al.
The Journal of biological chemistry, 276(11), 8104-8110 (2000-12-13)
Amphiphysin 1 is a phosphoprotein expressed at high levels in neurons, where it participates in synaptic vesicle endocytosis and neurite outgrowth. It is a substrate for cyclin-dependent kinase (cdk) 5, a member of the cyclin-dependent protein kinase family, which has
H Lin et al.
Cell death and differentiation, 14(3), 607-615 (2006-08-26)
Although Abl functions in mature neurons, work to date has not addressed Abl's role on Cdk5 in neurodegeneration. We found that beta-amyloid (Abeta42) initiated Abl kinase activity and that blockade of Abl kinase rescued both Drosophila and mammalian neuronal cells
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