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Merck
CN

05-364

抗-Cdk5抗体，克隆DC17

clone DC17, Upstate®, from mouse

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
DC17, monoclonal
Application:
ICC, IP, WB
Citations:
30

主要文件

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biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

DC17, monoclonal

species reactivity

mouse, human, Drosophila, rat

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG1

NCBI accession no.

NP_004926

UniProt accession no.

Q00535

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

fruit fly ... Cdk5(36727)
human ... CDK5(1020)
mouse ... Cdk5(12568)
rat ... Cdk5(140908)

General description

33kDa

Immunogen

重组人cdk5

Application

抗-Cdk5 抗体（克隆 DC17）是用于检测Cdk5 的高质量小鼠单克隆抗体，&已在 IP、WB、ICC 中进行了验证。
研究子类别
细胞周期，DNA 复制&修复
研究类别
表观遗传学&核功能

Biochem/physiol Actions

cdk5

Physical form

0.1M Tris-甘氨酸（pH 7.4），0.15M NaCl，含0.05％叠氮化钠。
形式：纯化
蛋白G层析

Preparation Note

在-20°C下可保存2年

Analysis Note

对照
阳性抗原对照：货号12-301，未刺激的A431细胞裂解液。 加入2.5µL 2-巯基乙醇/100µL裂解液，煮沸5分钟以 减少制备量。在微凝胶每个泳道上样20µg经还原的裂解液。
通过免疫印迹对未刺激的人A431细胞、小鼠Wehi 细胞或大鼠PC12细胞的RIPA裂解液进行了常规评估

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Seungil Paik et al.
Biomedicines, 9(1) (2021-01-07)
Somatostatin is involved in the regulation of multiple signaling pathways and affords neuroprotection in response to neurotoxins. In the present study, we investigated the role of Somatostatin-14 (SST) in cell viability and the regulation of phosphorylation of Collapsin Response Mediator
The presence of active Cdk5 associated with p35 in astrocytes and its important role in process elongation of scratched astrocyte.
Yi He,Hui-Li Li,Wei-Yan Xie,Chun-Zhang Yang,Albert Cheung Hoi Yu,Yun Wang
Glia null
K Sobue et al.
The Journal of biological chemistry, 275(22), 16673-16680 (2000-04-06)
Neuronal Cdc2-like protein kinase (NCLK), a approximately 58-kDa heterodimer, was isolated from neuronal microtubules (Ishiguro, K., Takamatsu, M., Tomizawa, K., Omori, A., Takahashi, M., Arioka, M., Uchida, T. and Imahori, K. (1992) J. Biol. Chem. 267, 10897-10901). The biochemical nature
Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus.
Yin, DM; Huang, YH; Zhu, YB; Wang, Y
The Journal of Neuroscience null
H Lin et al.
Cell death and differentiation, 14(3), 607-615 (2006-08-26)
Although Abl functions in mature neurons, work to date has not addressed Abl's role on Cdk5 in neurodegeneration. We found that beta-amyloid (Abeta42) initiated Abl kinase activity and that blockade of Abl kinase rescued both Drosophila and mammalian neuronal cells
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