生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
AF4, monoclonal
种属反应性
human
制造商/商品名称
Upstate®
技术
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... IQGAP1(8826)
一般描述
185kDa
免疫原
A Glu-Glu tagged C-terminal fragment corresponding to amino acids 863-1657 of human IQGAP1, purified from baculovirus infected insect cells
应用
Detect IQGAP1 using this Anti-IQGAP1 Antibody, clone AF4 validated for use in IP & WB.
Research Category
Signaling
Signaling
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
生化/生理作用
IQGAP1, not IQGAP2
外形
Protein G Chromatography
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
制备说明
2 years at -20°C
分析说明
routinely evaluated by immunoblot on HepG2 RIPA cell lysate
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
Binding of myosin essential light chain to the cytoskeleton-associated protein IQGAP1.
Weissbach, L, et al.
Biochemical and biophysical research communications, 251, 269-276 (1998)
Kai-Min Lin et al.
Journal of virology, 97(8), e0054023-e0054023 (2023-07-28)
Epstein-Barr virus (EBV) is a human oncogenic γ-herpesvirus that establishes persistent infection in more than 90% of the world's population. EBV has two life cycles, latency and lytic replication. Reactivation of EBV from latency to the lytic cycle is initiated
IQGAP1 involvement in MTOC and granule polarization in NK-cell cytotoxicity.
Namita Kanwar,John A Wilkins
European Journal of Immunology null
Katherine L Jameson et al.
Nature medicine, 19(5), 626-630 (2013-04-23)
Upregulation of the ERK1 and ERK2 (ERK1/2) MAP kinase (MAPK) cascade occurs in >30% of cancers, often through mutational activation of receptor tyrosine kinases or other upstream genes, including KRAS and BRAF. Efforts to target endogenous MAPKs are challenged by
S Kuroda et al.
Biochemical and biophysical research communications, 262(1), 1-6 (1999-08-17)
Cell-cell adhesion is a dynamic process in various cellular and developmental situations. Cadherins, well-known Ca(2+)-dependent adhesion molecules, are thought to play a major role in the regulation of cell-cell adhesion. However, the molecular mechanism underlying the rearrangement of cadherin-mediated cell-cell
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