biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
4A794, monoclonal
species reactivity
rat, human
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... TERF2(7014)
General description
66 kDa
TRF2是一种广泛表达的蛋白，与端粒长度的控制有关。与TRF1类似，TRF2含有一个Myb相关DNA结合基序。它结合双重TTAGGG重复序列，并位于中期染色体的所有人端粒中。TRF2通过维持端粒终点的正确结构，保护染色体末端。突变型TRF2的使用与TRF2预防原代人细胞衰老的作用有关。最近的研究表明TRF2的抑制导致一些类型的哺乳细胞的细胞凋亡。TRF2 在许多人肿瘤中过度表达，研究表明在小鼠癌症发生模型中TRF2的过度表达是致癌性的。
Immunogen
His标记的融合蛋白，对应于全长TRF2（端粒重复结合因子2），在杆状病毒中表达
Application
抗TRF2 抗体（克隆4A794）是一种小鼠单克隆抗体，可用于检测TRF2 （也称为端粒重复结合因子1 & 已在ICC & WB中进行测试。
研究子类别
细胞周期，DNA 复制&修复
细胞周期，DNA 复制&修复
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
可识别TRF2。
Physical form
形式：纯化
蛋白G纯化
蛋白G纯化的小鼠IgG1，溶于含0.05% 叠氮化钠的PBS中。
Preparation Note
自收到之日起在-20°C可稳定保存2年。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始小瓶进行离心。
Analysis Note
对照
阳性抗原对照：货号12-303，Jurkat细胞裂解液。
阳性抗原对照：货号12-303，Jurkat细胞裂解液。
通过免疫印迹对人Jurka细胞的RIPA 裂解液、HeLa细胞核提取物或大鼠L6 RIPA细胞裂解液进行了常规评估
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
相关内容
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| 货号 | GTIN |
|---|---|
| 05-521 | 04053252329319 |