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Merck
CN

05-521

抗-TRF2抗体，克隆 4A794

clone 4A794, Upstate®, from mouse

别名:

Anti-TRBF2, Anti-TRF2

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

主要文件

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产品名称

抗-TRF2抗体，克隆 4A794, clone 4A794, Upstate®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4A794, monoclonal

species reactivity

rat, human

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_005652

UniProt accession no.

Q15554

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... TERF2(7014)

相关类别

Analysis Note

对照
阳性抗原对照：货号12-303，Jurkat细胞裂解液。
通过免疫印迹对人Jurka细胞的RIPA 裂解液、HeLa细胞核提取物或大鼠L6 RIPA细胞裂解液进行了常规评估

Application

抗TRF2 抗体（克隆4A794）是一种小鼠单克隆抗体，可用于检测TRF2 （也称为端粒重复结合因子1 & 已在ICC & WB中进行测试。
研究子类别
细胞周期，DNA 复制&修复
研究类别
表观遗传学&核功能

Biochem/physiol Actions

可识别TRF2。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

66 kDa
TRF2是一种广泛表达的蛋白，与端粒长度的控制有关。与TRF1类似，TRF2含有一个Myb相关DNA结合基序。它结合双重TTAGGG重复序列，并位于中期染色体的所有人端粒中。TRF2通过维持端粒终点的正确结构，保护染色体末端。突变型TRF2的使用与TRF2预防原代人细胞衰老的作用有关。最近的研究表明TRF2的抑制导致一些类型的哺乳细胞的细胞凋亡。TRF2 在许多人肿瘤中过度表达，研究表明在小鼠癌症发生模型中TRF2的过度表达是致癌性的。

Immunogen

His标记的融合蛋白，对应于全长TRF2（端粒重复结合因子2），在杆状病毒中表达

Physical form

形式：纯化
蛋白G纯化
蛋白G纯化的小鼠IgG1，溶于含0.05% 叠氮化钠的PBS中。

Preparation Note

自收到之日起在-20°C可稳定保存2年。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始小瓶进行离心。

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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hnRNP A2, a potential ssDNA/RNA molecular adapter at the telomere.
Moran-Jones, K; Wayman, L; Kennedy, DD; Reddel, RR; Sara, S; Snee, MJ; Smith, R
Nucleic Acids Research null
Clara Lopes Novo et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(9), 3632-3642 (2013-06-05)
Telomeres are major regulators of genome stability and cell proliferation. A detailed understanding of the mechanisms involved in their maintenance is of foremost importance. Of those, telomere chromatin remodeling is probably the least studied; thus, we intended to explore the
S K Manna et al.
Journal of immunology (Baltimore, Md. : 1950), 165(9), 4927-4934 (2000-10-25)
We and others have reported that IFN-alpha potentiates the apoptotic effects of TNF through a mechanism that is not understood. Because the nuclear transcription factors NF-kappaB and AP-1 have recently been reported to mediate anti-apoptosis and cell survival, we hypothesized
Daniel H Lackner et al.
PloS one, 6(6), e21407-e21407 (2011-07-16)
Telomeres are nucleoprotein complexes which protect the ends of linear chromosomes from detection as DNA damage and provide a sequence buffer against replication-associated shortening. In mammals, telomeres consist of repetitive DNA sequence (TTAGGG) and associated proteins. The telomeric core complex
M Marchesini et al.
Oncogene, 35(14), 1811-1821 (2015-06-30)
Telomeres interact with numerous proteins, including components of the shelterin complex, whose alteration, similarly to proliferation-induced telomere shortening, initiates cellular senescence. In tumors, telomere length is maintained by Telomerase activity or by the Alternative Lengthening of Telomeres mechanism, whose hallmark
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