05-652
抗-MUC1/episialin抗体（克隆214D4）
clone 214D4, Upstate®, from mouse
别名:
Breast carcinoma-associated antigen DF3, Carcinoma-associated mucin, Episialin, H23AG, PEMT, Peanut-reactive urinary mucin, PUM, Polymorphic epithelial mucin, PEM, Tumor-associated epithelial membrane antigen, EMA, Tumor-associated mucin, CD227
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
214D4, monoclonal
Application:
FACS, IHC
Citations:
17
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
clone
214D4, monoclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
flow cytometry: suitable, immunohistochemistry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
相关类别
General description
未给出
Immunogen
融合蛋白，人 b-gal-episialin/MUC1 重复结构域
Application
抗-MUC1/episialin 抗体（克隆214D4）可检测MUC1/episialin水平&已有相关文献发表 & 经验证可用于 FC、IH。
研究子类别
ECM 蛋白
ECM 蛋白
研究类别
细胞结构
细胞结构
Biochem/physiol Actions
MUC1/episialin
Physical form
0.1M Tris-甘氨酸，pH 7.4，0.15M NaCl，0.05％叠氮化钠，然后添加甘油至30％
形式：纯化
蛋白G层析
Preparation Note
在-20°C下可保存2年
Analysis Note
通过免疫组化进行常规评估
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
存储类别
10 - Combustible liquids
wgk
WGK 1
Ilene K Gipson et al.
PloS one, 9(6), e100393-e100393 (2014-06-27)
Membrane-anchored mucins are present in the apical surface glycocalyx of mucosal epithelial cells, each mucosal epithelium having at least two of the mucins. The mucins have been ascribed barrier functions, but direct comparisons of their functions within the same epithelium
A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1.
Wesseling, J, et al.
Molecular Biology of the Cell, 7, 565-577 (1996)
Y Tatematsu et al.
Bone marrow transplantation, 47(3), 416-425 (2011-05-17)
The ocular surface is a frequent target tissue of mucosal chronic GVHD (cGVHD). We investigated the histopathological features of the conjunctival microvilli in patients with cGVHD. Conjunctival tissue specimens from patients with cGVHD or Sjögren's syndrome (SS) or from healthy
Monoclonal antibodies against the nonmucin domain of MUC1/episialin.
Hilkens, J and Boer, M
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 19 Suppl 1, 67-70 (1998)
Pablo Argüeso et al.
The Journal of biological chemistry, 284(34), 23037-23045 (2009-06-27)
Maintenance of an intact mucosal barrier is critical to preventing damage to and infection of wet-surfaced epithelia. The mechanism of defense has been the subject of much investigation, and there is evidence now implicating O-glycosylated mucins on the epithelial cell
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