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Merck
CN

05-675

Anti-Myelin Basic Protein Antibody

UPSTATE®, mouse monoclonal, SKB3

别名:

Anti-C76307, Anti-Hmbpr, Anti-R75289, Anti-golli-mbp, Anti-jve, Anti-mld, Anti-shi

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关于此项目

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
SKB3, monoclonal
Species reactivity:
rat, human, mouse
Application:
western blot
Technique(s):
western blot: suitable
Citations:
19
Uniprot accession no.:
P02686

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产品名称

Anti-MBP Antibody, clone SKB3, clone SKB3, Upstate®, from mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

SKB3, monoclonal

species reactivity

rat, human, mouse

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_002385

UniProt accession no.

P02686

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MBP(4155)
mouse ... Mbp(17196)
rat ... Mbp(24547)

Analysis Note

Control
Brain tissue
routinely evaluated by immunoblot on RIPA lysates from mouse and rat brain tissue preparations

Application

Detect MBP using this Anti-MBP Antibody, clone SKB3 validated for use in WB.
Research Category
Signaling
Research Sub Category
MAP Kinases

Biochem/physiol Actions

Recognizes MBP.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

18-20 kDa

Immunogen

Peptide corresponding to the human myelin basic protein sequence containing amino acid Thr98

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified
Protein G Purified
Protein G Purified immunoglobulin in Immunoaffinity Purified immunoglobulin in 0.02M Phosphate Buffer, 0.25 M NaCl, pH 7.6 with 15 mg/mL BSA containing no preservatives.

Preparation Note

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

wgk

WGK 1

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Monica Giannotta et al.
EMBO molecular medicine, 6(2), 239-258 (2014-01-01)
Muscular dystrophies are severe genetic diseases for which no efficacious therapies exist. Experimental clinical treatments include intra-arterial administration of vessel-associated stem cells, called mesoangioblasts (MABs). However, one of the limitations of this approach is the relatively low number of cells
Robert Sparks et al.
The Journal of biological chemistry, 294(41), 14896-14910 (2019-08-16)
The metabolic consequences and sequelae of obesity promote life-threatening morbidities. PKCδI is an important elicitor of inflammation and apoptosis in adipocytes. Here we report increased PKCδI activation via release of its catalytic domain concurrent with increased expression of proinflammatory cytokines
Samantha K Barton et al.
Frontiers in neuroscience, 15, 705306-705306 (2021-09-21)
Pathological hallmarks of amyotrophic lateral sclerosis (ALS), including protein misfolding, are well established in oligodendrocytes. More recently, an RNA trafficking deficit of key myelin proteins has been suggested in oligodendrocytes in ALS but the extent to which this affects myelination
Identification of multiple in vivo phosphorylation sites in rabbit myelin basic protein.
Martenson, R E, et al.
The Journal of Biological Chemistry, 258, 930-937 (1983)
Zhongcan Chen et al.
Human molecular genetics, 26(22), 4494-4505 (2017-10-04)
Pathogenic leucine-rich repeat kinase 2 (LRRK2) mutations are recognized as the most common cause of familial Parkinson's disease in certain populations. Recently, LRRK2 mutations were shown to be associated with a higher risk of hormone-related cancers. However, how LRRK2 itself
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