产品名称
Anti-Mps1 Antibody, NT, clone 3-472-1, clone 3-472-1, Upstate®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
3-472-1, monoclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... C5AR2(27202)
Analysis Note
routinely evaluated by immunoblot on HeLa total cell extract
Application
Detect Mps1 with Anti-Mps1 Antibody, NT, clone 3-472-1 (Mouse Monoclonal Antibody), that has been shown to work in WB.
General description
97kDa
Mps1 was previously known as TTK/PYK
Physical form
Format: Purified
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Mandar R Bhonde et al.
The Journal of biological chemistry, 281(13), 8675-8685 (2006-02-01)
DNA damage induced by the topoisomerase I inhibitor irinotecan (CPT-11) triggers in p53(WT) colorectal carcinoma cells a long term cell cycle arrest and in p53MUT cells a transient arrest followed by apoptosis (Magrini, R., Bhonde, M. R., Hanski, M. L.
Recruitment of Mad1 to metaphase kinetochores is sufficient to reactivate the mitotic checkpoint.
Ballister, ER; Riegman, M; Lampson, MA
The Journal of cell biology null
Christopher P Mattison et al.
Cell cycle (Georgetown, Tex.), 10(5), 783-793 (2011-02-18)
The Mps1 family of protein kinases contributes to cell cycle control by regulating multiple microtubule cytoskeleton activities. We have uncovered a new Mps1 substrate that provides a novel link between Mps1 and the actin cytoskeleton. We have identified a conserved
Elodie Montaudon et al.
Nature communications, 11(1), 4053-4053 (2020-08-15)
A significant proportion of patients with oestrogen receptor (ER) positive breast cancers (BC) develop resistance to endocrine treatments (ET) and relapse with metastatic disease. Here we perform whole exome sequencing and gene expression analysis of matched primary breast tumours and
A Koch et al.
Oncogene, 35(19), 2518-2528 (2015-09-15)
Mps1/TTK is a dual-specificity kinase, with an essential role in mitotic checkpoint signaling, which has emerged as a potential target in cancer therapy. Several Mps1/TTK small-molecule inhibitors have been described that exhibit promising activity in cell culture and xenograft models.
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