05-826
Anti-Bcl-2 Antibody, clone AW604
clone AW604, Upstate®, from mouse
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
AW604, monoclonal
Application:
immunoprecipitation (IP)
western blot
western blot
Species reactivity:
human
Citations:
18
Technique(s):
immunoprecipitation (IP): suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-Bcl-2 Antibody, clone AW604, clone AW604, Upstate®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
AW604, monoclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... BCL2(596)
Analysis Note
routinely evaluated by immunoblot on Raji RIPA cell lysate
Application
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
BCL2 & Inhibition
BCL2 & Inhibition
This Anti-Bcl-2 Antibody, clone AW604 is validated for use in IP, WB for the detection of Bcl-2.
Biochem/physiol Actions
Bcl-2
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
26kDa
Immunogen
KLH-conjugated, synthetic peptide corresponding to amino acids 41-54 (C-GAAPAPGIFSSQPG) of human Bcl-2
Other Notes
Replaces: 04-436; OP60-100UG
Physical form
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein G Purified
Preparation Note
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Ekaterina Kim et al.
Leukemia, 34(6), 1588-1598 (2019-12-22)
Despite major improvements in treatment outcome with novel targeted therapies, such as the Bruton tyrosine kinase (BTK) inhibitor ibrutinib, chronic lymphocytic leukemia (CLL) remains incurable in the majority of patients. Activation of PI3K, NF-κB, and/or MYC has been linked to
S Krajewski et al.
Cancer research, 53(19), 4701-4714 (1993-10-01)
A multidisciplinary approach was taken to investigate the intracellular locations of the 26-kDa integral membrane protein encoded by the bcl-2 gene. Subcellular fractionation analysis of a t(14;18)-containing lymphoma cell line revealed the presence of Bcl-2 protein in nuclear, heavy-membrane, and
Programmed cell death: apoptosis and oncogenesis.
Williams, G T
Cell, 65, 1097-1098 (1991)
Maria Elena Mantione et al.
Cell death & disease, 15(3), 224-224 (2024-03-18)
Microenvironmental signals strongly influence chronic lymphocytic leukemia (CLL) cells through the activation of distinct membrane receptors, such as B-cell receptors, and inflammatory receptors, such as Toll-like receptors (TLRs). Inflammatory pathways downstream of these receptors lead to NF-κB activation, thus protecting
Maria Elena Mantione et al.
Frontiers in oncology, 12, 894413-894413 (2022-07-12)
Renal cell carcinoma is highly inflamed, and tumor cells are embedded into a microenvironment enriched with IL1. While inflammatory pathways are well characterized in the immune system, less is known about these same pathways in epithelial cells; it is unclear
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