05-832
Anti-LKB1 Antibody, clone 5c10
clone 5c10, Upstate®, from mouse
别名:
Anti-LKB1, Anti-hLKB1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
5c10, monoclonal
Application:
immunocytochemistry
western blot
western blot
Species reactivity:
mouse, rat, human
Citations:
12
Technique(s):
immunocytochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-LKB1 Antibody, clone 5c10, clone 5c10, Upstate®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
5c10, monoclonal
species reactivity
mouse, rat, human
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... STK11(6794)
Analysis Note
Control
Rat2 cell lysate
Rat2 cell lysate
routinely evaluated by immunoblot on RIPA lysates from Rat2 cells
Application
Research Category
Signaling
Signaling
Research Sub Category
Insulin/Energy Signaling
Insulin/Energy Signaling
This Anti-LKB1 Antibody, clone 5c10 is validated for use in IC, WB for the detection of LKB1.
Biochem/physiol Actions
Recognizes LKB1.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
55 kDa
Immunogen
GST fusion protein corresponding to residues 1-433 of human LKB1
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Protein G Purified
Protein G Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl and 0.05% Sodium Azide, pH 7.4.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Yuji Nakada et al.
PloS one, 8(9), e73449-e73449 (2013-10-03)
Germline mutations in the LKB1 gene (also known as STK11) cause the Peutz-Jeghers Syndrome, and somatic loss of LKB1 has emerged as causal event in a wide range of human malignancies, including melanoma, lung cancer, and cervical cancer. The LKB1
Naoyuki Asada et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(26), 8852-8865 (2010-07-02)
Neuronal migration is an essential process for the development of the cerebral cortex. We have previously shown that LKB1, an evolutionally conserved polarity kinase, plays a critical role in neuronal migration in the developing neocortex. Here we show that LKB1
A F Baas et al.
The EMBO journal, 22(12), 3062-3072 (2003-06-14)
The LKB1 gene encodes a serine/threonine kinase mutated in Peutz-Jeghers cancer syndrome. Despite several proposed models for LKB1 function in development and in tumour suppression, the detailed molecular action of LKB1 remains undefined. Here, we report the identification and characterization
Molecular diagnosis and clinical relevance of t(9;22), t(4;11) and t(1 ;19) chromosome abnormalities in a consecutive group of 141 adult patients with acute lymphoblastic leukemia
Rambaldi, A., et al
Leukemia & Lymphoma, 21, 457-466 (1996)
Samantha M Behunin et al.
Archives of biochemistry and biophysics, 601, 32-41 (2016-03-15)
Contractile perturbations downstream of Ca(2+) binding to troponin C, the so-called sarcomere-controlled mechanisms, represent the earliest indicators of energy remodeling in the diseased heart [1]. Central to cellular energy "sensing" is the adenosine monophosphate-activated kinase (AMPK) pathway, which is known
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