05-857
抗磷酸化-Src家族（Tyr416）抗体，克隆2N8，兔单克隆
clone 2N8, Upstate®, from rabbit
别名:
KAT13A
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
2N8, monoclonal
Species reactivity:
vertebrates, mouse
Application:
WB
Citations:
10
biological source
rabbit
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
2N8, monoclonal
species reactivity
vertebrates, mouse
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pTyr416)
Quality Level
Gene Information
human ... SRC(6714)
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General description
60kDa
Immunogen
含有序列...NE[pY]TA的合成肽，其中pY对应于c-Src 416位的磷酸酪氨酸。
Application
研究子类别
细胞骨架信号转导
细胞骨架信号转导
研究类别
信号传导
信号传导
经验证，该抗磷酸化Src家族（Tyr416）抗体（克隆2N8）可用于WB检测磷酸化Src家族（Tyr416）。
Biochem/physiol Actions
磷酸化-c-Src (Tyr416)
Physical form
形式：纯化
蛋白A纯化
Preparation Note
自运送之日起在-20°C下保存2年
Analysis Note
通过使用抗Src，克隆GD11琼脂糖珠（目录号16-186）免疫印迹从NIH/3T3 RIPA裂解液中免疫沉淀的内源性磷酸化-c-Src进行常规评估
Other Notes
替代：16-249
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 1
Molecular interdiction of Src-family kinase signaling in hematopoietic cells.
Geahlen, Robert L, et al.
Oncogene, 23, 8024-8032 (2004)
Structure and regulation of Src family kinases.
Boggon, Titus J and Eck, Michael J
Oncogene, 23, 7918-7927 (2004)
The interplay between Src family kinases and receptor tyrosine kinases.
Bromann, Paul A, et al.
Oncogene, 23, 7957-7968 (2004)
Suowen Xu et al.
Cellular signalling, 28(3), 117-124 (2015-12-27)
Endothelial dysfunction, characterized by impaired activation of endothelial nitric oxide (NO) synthase (eNOS) and ensued decrease of NO production, is a common mechanism of various cardiovascular pathologies, including hypertension and atherosclerosis. Laminar blood flow-mediated specific signaling cascades modulate vascular endothelial
Src protein-tyrosine kinase structure and regulation.
Roskoski, Robert
Biochemical and biophysical research communications, 324, 1155-1164 (2004)
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