生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
ascites fluid
抗体产品类型
primary antibodies
克隆
PRK8, monoclonal
种属反应性
human, mouse
制造商/商品名称
Upstate®
技术
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
unmodified
基因信息
human ... PARK2(5071)
一般描述
52kDa May be observed as a doublet at 52 and 46kDa
免疫原
Full length recombinant human Parkin. Epitope has been mapped to the second ring domain (aa 399-465)
应用
Anti-Parkin Antibody, clone PRK8 detects level of Parkin & has been published & validated for use in IP, WB, IC, IH.
生化/生理作用
Parkin
分析说明
routinely evaluated by immunoblot on RIPA lysates from HEK293 cells
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
Genotype-phenotype correlation: familial Parkinson disease.
Mori, Hideo, et al.
Neuropathology : Official Journal of the Japanese Society of Neuropathology, 23, 90-94 (2003)
Nobutaka Hattori et al.
Lancet (London, England), 364(9435), 722-724 (2004-08-25)
The cause and pathogenesis of Parkinson's disease remain unknown; mitochondrial dysfunction, oxidative damage, environmental factors, and genetic predisposition might all be involved. Identification of the causative genes for familial Parkinson's diseases allow study of the pathogenesis of the disease at
Christian Pennanen et al.
Journal of cell science, 127(Pt 12), 2659-2671 (2014-04-30)
Cardiomyocyte hypertrophy has been associated with diminished mitochondrial metabolism. Mitochondria are crucial organelles for the production of ATP, and their morphology and function are regulated by the dynamic processes of fusion and fission. The relationship between mitochondrial dynamics and cardiomyocyte
Molecular pathways of neurodegeneration in Parkinson's disease.
Dawson, Ted M and Dawson, Valina L
Science (New York, N.Y.), 302, 819-822 (2003)
Keiji Tanaka et al.
Biochimica et biophysica acta, 1695(1-3), 235-247 (2004-12-02)
The ubiquitin-proteasome system (UPS) is important for intracellular proteolysis, and is responsible for a diverse array of biologically important cellular processes, such as cell-cycle progression, signaling cascades and developmental programs. This system is also involved in the protein quality control
商品
Autophagy is a regulated process involved in cell growth, development, and recycling of cytoplasmic components in cells.
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