05-903
Anti-GSK3α/β Antibody, rabbit monoclonal
Upstate®, from rabbit
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
monoclonal
Application:
IP, WB
Citations:
13
biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
monoclonal
species reactivity
human, mouse
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GSK3A(2931)
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General description
Mr 46kDa (beta) and 51kDa (alpha)
Immunogen
N-terminal 6His-tagged recombinant full length human GSK3β
Application
Anti-GSK3α/β Antibody is an antibody against GSK3α/β for use in IP & WB.
Biochem/physiol Actions
GSK3 alpha and beta
Predicted to cross-react with rat based on sequence homology
Physical form
Format: Purified
Analysis Note
Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
routinely evaluated by immunoblot on lysates from HEK293 cells
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Yasuhiro Nishino et al.
Circulation research, 103(3), 307-314 (2008-06-28)
The inactivation of glycogen synthase kinase-3beta (GSK-3beta) is proposed as the event integrating protective pathways initiated by preconditioning and other interventions. The inactivation of GSK-3 is thought to decrease the probability of opening of the mitochondrial permeability transition pore. The
Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication.
Chuluunbaatar, U; Roller, R; Feldman, ME; Brown, S; Shokat, KM; Mohr, I
Genes & Development null
Jen Q Pan et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 36(7), 1397-1411 (2011-03-11)
Bipolar disorder (BP) is a debilitating psychiatric disorder, affecting ∼2% of the worldwide population, for which the etiological basis, pathogenesis, and neurocircuitry remain poorly understood. Individuals with BP suffer from recurrent episodes of mania and depression, which are commonly treated
Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes.
Jope, Richard S
Trends in Pharmacological Sciences, 24, 441-443 (2003)
GSK-3: tricks of the trade for a multi-tasking kinase.
Doble, Bradley W and Woodgett, James R
Journal of Cell Science, 116, 1175-1186 (2003)
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