06-1036
抗-March5抗体
serum, from rabbit
别名:
membrane-associated ring finger (C3HC4) 5, Membrane-associated RING finger protein 5, RING finger protein 153, E3 ubiquitin-protein ligase MARCH5, Mitochondrial ubiquitin ligase, Membrane-associated RING-CH protein V
产品名称
抗-March5抗体, serum, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
species reactivity (predicted by homology)
mouse (based on 100% sequence homology), rat (based on 100% sequence homology)
technique(s)
immunocytochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MARCHF5(54708)
Analysis Note
对照
HL-60细胞裂解液
HL-60细胞裂解液
通过蛋白质印迹对HL-60细胞裂解液进行了评估。
蛋白质印迹分析：该抗体以1：2,000的稀释度在10 µg HL-60细胞裂解液中检测到March5。
蛋白质印迹分析：该抗体以1：2,000的稀释度在10 µg HL-60细胞裂解液中检测到March5。
Application
免疫细胞化学分析：该抗体的代表性批次已被独立实验室用于IC。(Korfali, N., et al. (2010).Mol Cell Proteomics.9:2571-2585.)
抗March5抗体是一种兔多克隆抗体，可用于检测March5（也被称为膜相关环指蛋白5）。&其已在WB，ICC中进行验证。
研究子类别
泛素 & 泛素代谢
泛素 & 泛素代谢
研究类别
表观遗传学&核功能
表观遗传学&核功能
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
膜相关的RING-CH蛋白5（March5），也称为NKP66，被认为是位于线粒体膜上的线粒体泛素连接酶。March5具有植物同源域（PHD）基序，这对于E3泛素连接酶作用至关重要。MARCH 5也被认为具有四个跨膜结构域。March5与线粒体裂变和分裂有关。March5似乎还通过与突变型超氧化物歧化酶1（mSOD1）相互作用并阻止mSOD1引起损伤而对线粒体功能障碍具有防御作用。mSOD1损伤与肌萎缩性侧索硬化症的发作和进展有关。
观测值〜52 kDa
Immunogen
对应于人March5的KLH偶联线性肽。
。
。
Physical form
兔多克隆抗血清，含0.05％叠氮化钠。
未纯化
Preparation Note
自收到之日起，在-20°C条件下可稳定保存1年。
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于-20°C。避免反复冻融循环，以免损坏IgG和影响产品性能。
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于-20°C。避免反复冻融循环，以免损坏IgG和影响产品性能。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 1
The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture.
Korfali, N; Wilkie, GS; Swanson, SK; Srsen, V; Batrakou, DG; Fairley, EA; Malik et al.
Molecular and Cellular Proteomics null
Manuel D Haschka et al.
Cell death and differentiation, 27(8), 2297-2312 (2020-02-06)
Cells experiencing delays in mitotic progression are prone to undergo apoptosis unless they can exit mitosis before proapoptotic factors reach a critical threshold. Microtubule targeting agents (MTAs) arrest cells in mitosis and induce apoptotic cell death engaging the BCL2 network.
Seiji Arai et al.
eLife, 9 (2020-06-03)
MCL1 has critical antiapoptotic functions and its levels are tightly regulated by ubiquitylation and degradation, but mechanisms that drive this degradation, particularly in solid tumors, remain to be established. We show here in prostate cancer cells that increased NOXA, mediated
Esmee Vringer et al.
The EMBO journal, 43(6), 904-930 (2024-02-10)
Mitochondrial outer membrane permeabilisation (MOMP) is often essential for apoptosis, by enabling cytochrome c release that leads to caspase activation and rapid cell death. Recently, MOMP has been shown to be inherently pro-inflammatory with emerging cellular roles, including its ability
Alban Ordureau et al.
Molecular cell, 77(5), 1124-1142 (2020-03-07)
The ubiquitin ligase Parkin, protein kinase PINK1, USP30 deubiquitylase, and p97 segregase function together to regulate turnover of damaged mitochondria via mitophagy, but our mechanistic understanding in neurons is limited. Here, we combine induced neurons (iNeurons) derived from embryonic stem
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持