06-1334
Anti-phospho-TAB1 (Thr431) Antibody
from rabbit, purified by affinity chromatography
别名:
TGF-beta activated kinase 1/MAP3K7 binding protein 1, TAK1-binding protein 1, transforming growth factor beta-activated kinase-binding protein 1, mitogen-activated protein kinase kinase kinase 7 interacting protein 1, Mitogen-activated protein kinase kin
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
rat, human, horse, mouse
种属反应性（根据同源性预测）
equine (based on 100% sequence homology), ox (based on 100% sequence homology)
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
phosphorylation (pThr431)
基因信息
human ... TAB1(10454)
一般描述
TAK1 binding protein 1 (TAB1) is thought to activate TAK1 MAPKKK in transforming growth factor-beta (TGF-beta) signaling. TAB1 can also associate with TAK1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. Through conformational changes, TAB1 is also thought to induce p38alpha autophosphorylation. It has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways.
~78 kDa observed. 55 kDa calculated. A higher molecular weight on western blot may be due to glycosylation. An uncharacterized band appears at ~42 and 50 kDa in some lysates.
免疫原
Epitope: Phosphorylated Thr431
KLH-conjugated linear peptide corresponding to human TAB1 phosphorylated at Thr431.
应用
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology
Immunoglobulins & Immunology
This Anti-phospho-TAB1 (Thr431) Antibody is validated for use in WB for the detection of phospho-TAB1 (Thr431).
生化/生理作用
This antibody recognizes TAB1 phosphorylated at Thr431.
外形
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
制备说明
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
L6 cell lysate
L6 cell lysate
Evaluated by Western Blot in L6 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected TAB1 on 10 µg of L6 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected TAB1 on 10 µg of L6 cell lysate.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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