06-1334
Anti-phospho-TAB1 (Thr431) Antibody
from rabbit, purified by affinity chromatography
别名:
TGF-beta activated kinase 1/MAP3K7 binding protein 1, TAK1-binding protein 1, transforming growth factor beta-activated kinase-binding protein 1, mitogen-activated protein kinase kinase kinase 7 interacting protein 1, Mitogen-activated protein kinase kin
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
rat, human, horse, mouse
Application:
WB
Citations:
4
biological source
rabbit
Quality Segment
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat, human, horse, mouse
species reactivity (predicted by homology)
equine (based on 100% sequence homology), ox (based on 100% sequence homology)
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pThr431)
Gene Information
human ... TAB1(10454)
General description
TAK1 binding protein 1 (TAB1) is thought to activate TAK1 MAPKKK in transforming growth factor-beta (TGF-beta) signaling. TAB1 can also associate with TAK1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. Through conformational changes, TAB1 is also thought to induce p38alpha autophosphorylation. It has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways.
~78 kDa observed. 55 kDa calculated. A higher molecular weight on western blot may be due to glycosylation. An uncharacterized band appears at ~42 and 50 kDa in some lysates.
Immunogen
Epitope: Phosphorylated Thr431
KLH-conjugated linear peptide corresponding to human TAB1 phosphorylated at Thr431.
Application
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology
Immunoglobulins & Immunology
This Anti-phospho-TAB1 (Thr431) Antibody is validated for use in WB for the detection of phospho-TAB1 (Thr431).
Biochem/physiol Actions
This antibody recognizes TAB1 phosphorylated at Thr431.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
L6 cell lysate
L6 cell lysate
Evaluated by Western Blot in L6 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected TAB1 on 10 µg of L6 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected TAB1 on 10 µg of L6 cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable