biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human, rat, bovine
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GNAI1(2770)
General description
40 kDa
Immunogen
10个残基的合成肽（KNNLKDCGLF），对应于Gia1和Gia2的C端
Application
可使用这种经验证可用于IC、IP & WB的Giα1/2抗体检测Giα1/2。
研究子类别
GPCR, cAMP/cGMP & 钙信号传导
GPCR, cAMP/cGMP & 钙信号传导
研究类别
信号传导
信号传导
Biochem/physiol Actions
可识别Giα1和Giα2。
Physical form
PBS（50 mM KHPO4、140 mM NaCl）稀释的兔血清。冷冻溶液
形式：纯化
Preparation Note
自收到之日起在-20°C可稳定保存2年。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始小瓶进行离心。
Analysis Note
通过免疫印迹法对大鼠脑微粒体制备物或小鼠3T3/A31成纤维细胞的溶解质膜进行了常规评估
对照
广泛表达
广泛表达
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 1
A Abbaci et al.
Oncogene, 37(6), 756-767 (2017-10-24)
B-cell chronic lymphocytic leukemia (B-CLL) cells are resistant to apoptosis, and consequently accumulate to the detriment of normal B cells and patient immunity. Because current therapies fail to eradicate these apoptosis-resistant cells, it is essential to identify alternative survival pathways
C J Lynch et al.
The Journal of clinical investigation, 83(6), 2050-2062 (1989-06-01)
Adenylate cyclase in liver plasma membranes from streptozotocin-diabetic (STZ) or BB/Wor spontaneously diabetic rats showed increased responsiveness to GTP, glucagon, fluoroaluminate, and cholera toxin. Basal or forskolin-stimulated activity was unchanged in STZ rats, but increased in BB/Wor rats. No change
P Barrett et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 14(11), 1619-1628 (2000-08-06)
Mimicking short photoperiod melatonin signals (16 h exposure) on primary cell cultures of melatonin target cells of the ovine pars tuberalis (PT) results in an enhanced cAMP response to forskolin stimulation relative to untreated cells, a phenomenon termed sensitization. The
Disulfide bonds in the extracellular calcium-polyvalent cation-sensing receptor correlate with dimer formation and its response to divalent cations in vitro
Ward, D. T., et al
The Journal of Biological Chemistry, 273, 14476-14483 (1998)
Jian Shi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(2), 702-715 (2015-10-16)
Depletion of sarcoplasmic reticulum (SR) Ca(2+) stores activates store-operated channels (SOCs) composed of canonical transient receptor potential (TRPC) 1 proteins in vascular smooth muscle cells (VSMCs), which contribute to important cellular functions. We have previously shown that PKC is obligatory
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