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Merck
CN

06-272

Anti-JAK1 Antibody

serum, Upstate®

别名:

Anti-AIIDE, Anti-JAK1B, Anti-JTK3

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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunoprecipitation (IP)
western blot
Species reactivity:
rabbit, hamster, mouse, human, rat
Citations:
51
Technique(s):
immunoprecipitation (IP): suitable
western blot: suitable
Uniprot accession no.:
P23458

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产品名称

Anti-JAK1 Antibody, serum, Upstate®

biological source

rabbit

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rabbit, hamster, mouse, human, rat

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_002227

UniProt accession no.

P23458

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... JAK1(3716)

Analysis Note

routinely evaluated by immunoblot on RIPA lysate from mouse CTLL lymphocytes, TF-1 erythroleukemic cells or mouse thymus

Application

Anti-JAK1 Antibody detects level of JAK1 & has been published & validated for use in IP & WB.
Research Category
Signaling
Research Sub Category
Immunological Signaling

Biochem/physiol Actions

JAK1

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

130 kDa

Immunogen

HPLC-purified (>98%) peptide corresponding to 21 amino acids of human JAK1 (KTLIEKERFYESRCRPVTPS-C)

Physical form

Antiserum
whole rabbit antiserum containing 0.05% sodium azide

Preparation Note

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

wgk

WGK 1

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C F Lai et al.
The Journal of biological chemistry, 274(12), 7793-7802 (1999-03-13)
Interleukin (IL)-6 is a major regulator of hepatic acute-phase plasma protein (APP) genes. The membrane-proximal 133-amino acid cytoplasmic domain of glycoprotein (gp) 130, containing one copy of the Box3 motif, is sufficient to transmit a productive signal to endogenous APP
Intermediate affinity interleukin-2 receptor mediates survival via a phosphatidylinositol 3-kinase-dependent pathway
Gonzalez-Garcia, A., et al
The Journal of Biological Chemistry, 272, 10220-10226 (1997)
Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation
Yu, C. L. and Burakoff, S. J.
The Journal of Biological Chemistry, 272, 14017-14020 (1997)
G J Brunn et al.
The Journal of biological chemistry, 270(19), 11628-11635 (1995-05-12)
The proliferation of activated T lymphocytes is critically dependent on the binding of the T-cell growth factors, interleukin (IL)-2 and IL-4, to distinct but evolutionarily related cell surface receptors. Previous results suggest that the IL-2 receptor (IL-2R) and IL-4R are
Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2.
Tortolani, P J, et al.
Blood, 85, 3444-3451 (1995)
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Pathways and Biomarkers of JAK/STAT Signaling

Pathways and Biomarkers of JAK/STAT Signaling

JAK/STAT Signaling Research Focus

The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia.

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