biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rabbit, hamster, mouse, human, rat
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... JAK1(3716)
General description
130 kDa
Immunogen
HPLC-purified (>98%) peptide corresponding to 21 amino acids of human JAK1 (KTLIEKERFYESRCRPVTPS-C)
Application
Anti-JAK1 Antibody detects level of JAK1 & has been published & validated for use in IP & WB.
Research Category
Signaling
Signaling
Research Sub Category
Immunological Signaling
Immunological Signaling
Biochem/physiol Actions
JAK1
Physical form
Antiserum
whole rabbit antiserum containing 0.05% sodium azide
Preparation Note
2 years at -20°C
Analysis Note
routinely evaluated by immunoblot on RIPA lysate from mouse CTLL lymphocytes, TF-1 erythroleukemic cells or mouse thymus
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
存储类别
10 - Combustible liquids
wgk
WGK 1
相关内容
Pathways and Biomarkers of JAK/STAT Signaling
The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia.
Intermediate affinity interleukin-2 receptor mediates survival via a phosphatidylinositol 3-kinase-dependent pathway
Gonzalez-Garcia, A., et al
The Journal of Biological Chemistry, 272, 10220-10226 (1997)
C F Lai et al.
The Journal of biological chemistry, 274(12), 7793-7802 (1999-03-13)
Interleukin (IL)-6 is a major regulator of hepatic acute-phase plasma protein (APP) genes. The membrane-proximal 133-amino acid cytoplasmic domain of glycoprotein (gp) 130, containing one copy of the Box3 motif, is sufficient to transmit a productive signal to endogenous APP
Svantje Sobotta et al.
Frontiers in physiology, 8, 775-775 (2017-10-25)
IL-6 is a central mediator of the immediate induction of hepatic acute phase proteins (APP) in the liver during infection and after injury, but increased IL-6 activity has been associated with multiple pathological conditions. In hepatocytes, IL-6 activates JAK1-STAT3 signaling
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 06-272 | 04053252326875 |