06-570-AF647
Anti-phospho Histone H3 (Ser10), Alexa Fluor™ 647 Conjugate Antibody
0.5 mg/mL, from rabbit
别名:
H3S10P, Histone H3 (phospho Ser10), H3 histone, family 3A, H3.3A, H3 histone, family 3B, H3.3B
产品名称
Anti-phospho Histone H3 (Ser10), Alexa Fluor™ 647 Conjugate Antibody, 0.5 mg/mL, from rabbit
biological source
rabbit
conjugate
ALEXA FLUOR™ 647
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
species reactivity (predicted by homology)
mouse (based on 100% sequence homology)
concentration
0.5 mg/mL
technique(s)
immunocytochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pSer10)
Quality Level
Gene Information
human ... HIST1H3F(8968)
Analysis Note
Evaluated by Immunocytochemistry in HeLa cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected phospho Histone H3 (Ser10) in HeLa cells.
Alexa Fluor™ is a registered trademark of Life Technologies.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected phospho Histone H3 (Ser10) in HeLa cells.
Alexa Fluor™ is a registered trademark of Life Technologies.
Application
Anti-phospho-H3 (Ser10), Alexa Fluor™ 647 Conjugate is a purified rabbit polyclonal antibody to detect Histone H3 phosphorylated at serine 10. This Ab is labeled with Alexa Fluor 647 and validated for use in IC. The unconjugated version of this antibody is published and proven in ICC, IP & WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. Histone proteins are highly post-translationally modified, and Histone H3 is the most extensively modified of the five histones. Histone H3 sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Di- and tri-methylation of histone H3 are gene silencing marks, while removal of these marks by the demethylase genes Jmjd1a and Jmjd2c leads to gene activation. This product is a conjugated version of Cat. No. 06-570.
~17 kDa observed (Refer to Cat. No. 06-570)
Immunogen
Linear peptide corresponding to Histone H3 phosphorylated at Ser10.
Physical form
Protein A purified
Purified rabbit conjugated antibody in buffer containing PBS and 15 mg/ml BSA with 0.1% Sodium Azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Hsu-Min Sung et al.
The Journal of cell biology, 222(12) (2023-11-13)
Current models posit that nuclear speckles (NSs) serve as reservoirs of splicing factors and facilitate posttranscriptional mRNA processing. Here, we discovered that ribotoxic stress induces a profound reorganization of NSs with enhanced recruitment of factors required for splice-site recognition, including
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