biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, rat, human, sheep
manufacturer/tradename
Upstate®
technique(s)
electrophoretic mobility shift assay: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... STAT5A(6776)
General description
90-95 kDa
Immunogen
peptide (CQELQKKAEHQVGEDG), corresponding to amino acids 66-80 of human STAT5 A and B
Application
Detect STAT5A/B also known as signal transducer & activator of transcription 5A/B with Anti-STAT5A/B Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in EMSA.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Biochem/physiol Actions
STAT5A and B
Physical form
Antiserum
whole rabbit antiserum containing 0.05% sodium azide
Preparation Note
2 years at -20°C
Analysis Note
routinely evaluated by Supershift
Other Notes
Replaces: 04-1016
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity.
Linda Scobie,Ralph D Hector,Louise Grant,Margaret Bell,Anne A Nielsen,Sharon Meikle et al.
Molecular Therapy null
Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells.
Dubois, S; Shou, W; Haneline, LS; Fleischer, S; Waldmann, TA; Muller, JR
Proceedings of the National Academy of Sciences of the USA null
Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways
Lange, C. A., et al
The Journal of Biological Chemistry, 273, 31308-31316 (1998)
J X Lin et al.
Immunity, 2(4), 331-339 (1995-04-01)
To understand the molecular bases for cytokine redundancy and pleiotropy, we have compared the Stat proteins activated in peripheral blood lymphocytes (PBLs) by cytokines with shared and distinct actions. Interleukin-2 (IL-2) rapidly activated Stat5 in fresh PBL, and Stat3 and
Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products.
Lin, J X, et al.
Molecular and cellular biology, 13, 6201-6210 (1993)
相关内容
The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia.
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