06-891
Anti-SMRTe Antibody
Upstate®, from rabbit
别名:
Anti-CTG26, Anti-N-CoR2, Anti-SMAP270, Anti-SMRT, Anti-SMRTE, Anti-SMRTE-tau, Anti-TNRC14, Anti-TRAC, Anti-TRAC-1, Anti-TRAC1
产品名称
Anti-SMRTe Antibody, Upstate®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
ChIP: suitable
immunocytochemistry: suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NCOR2(9612), TRAC(28755)
Analysis Note
Control
Mouse brain nuclear extract
Mouse brain nuclear extract
routinely evaluated by immunoblot on nuclear fraction from murine brain
Application
Anti-SMRTe Antibody is a high quality Rabbit Polyclonal Antibody for the detection of SMRTe & has been validated in ChIP, ICC & WB.
Research Category
Protein Trafficking
Epigenetics & Nuclear Function
Protein Trafficking
Epigenetics & Nuclear Function
Research Sub Category
RNA Metabolism & Binding Proteins
Histones
RNA Binding Protein (RBP)
RNA Metabolism & Binding Proteins
Histones
RNA Binding Protein (RBP)
Biochem/physiol Actions
SMRT isoforms
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
270kDa, 180kDa and 80kDa
SMRT is 1495 amino acids and contains an 8 amino acid sequence that is not present in SMRTe (SMRT-extended), which contains 2514 amino acids. SMRTe contains an N-terminal sequence spanning over 1,000 amino acids that is not present in SMRT, but that shows significant similarity with N-CoR. SMRTe expression is regulated during cell cycle progression, suggesting a role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways.
Immunogen
GST fusion-protein corresponding to residues 1146-1349 of human SMRTe
Physical form
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein A chromatography
Preparation Note
Store at 2–8°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT.
Takahashi, S; McConnell, MJ; Harigae, H; Kaku, M; Sasaki, T; Melnick, AM; Licht, JD
Blood null
TGF-? and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.
Takahashi, H; Kanno, T; Nakayamada, S; Hirahara, K; Sciume, G; Muljo, SA; Kuchen et al.
Nature Immunology null
Megan J Ritter et al.
Molecular metabolism, 53, 101315-101315 (2021-08-15)
The nuclear receptor corepressor 1 (NCOR1) and the silencing mediator of retinoic acid and thyroid hormone (SMRT, also known as NCOR2) play critical and specific roles in nuclear receptor action. NCOR1, both in vitro and in vivo specifically regulates thyroid hormone (TH)
Dong Wook Kim et al.
Human molecular genetics, 23(10), 2651-2664 (2014-01-02)
Mutations of the thyroid hormone receptor α gene (THRA) cause hypothyroidism in patients with growth and developmental retardation, and skeletal dysplasia. Genetic evidence indicates that the dominant negative activity of TRα1 mutants underlies pathological manifestations. Using a mouse model of
Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer.
Fernandez-Majada, V; Aguilera, C; Villanueva, A; Vilardell, F; Robert-Moreno, A; Aytes et al.
Proceedings of the National Academy of Sciences of the USA null
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