shipped in
dry ice
biological source
rabbit
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
target post-translational modification
phosphorylation (pThr187)
Quality Level
Gene Information
human ... CDKN1B(1027)
General description
27kDa
Immunogen
对应于人Kip1氨基酸179-190的KLH偶联合成肽（C-PNAGSVEQ[pT]PKK）
Application
抗磷酸化-Kip1（Thr187）抗体是一种高质量的兔多克隆抗体，用于检测 磷酸化-Kip1（Thr187），&已在 WB 中验证。
研究子类别
细胞周期，DNA 复制&修复
细胞周期，DNA 复制&修复
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
磷酸化Kip1
Physical form
0.2M Tris、0.15M NaCl、0.1mM EDTA、0.05％叠氮化钠，然后添加甘油至30％
免疫亲和层析
Preparation Note
在-20°C下保存1年
Analysis Note
通过免疫印迹法对HeLa 细胞RIPA裂解液进行了常规评估
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 1
p27KIP1, an inhibitor of cyclin-dependent kinases.
Koff, A and Polyak, K
Progress in Cell Cycle Research, 1, 141-147 (1995)
J Kato
Frontiers in bioscience : a journal and virtual library, 4, D787-D792 (1999-11-30)
The first gap phase (G1) in the mammalian cell cycle plays a pivotal role in determining whether or not cells are to initiate DNA replication. Progression through G1 phase and transition into S phase are positively and negatively regulated by
Oncostatin M induces growth arrest by inhibition of Skp2, Cks1, and cyclin A expression and induced p21 expression.
Halfter, H; Friedrich, M; Resch, A; Kullmann, M; Stogbauer, F; Ringelstein, EB; Hengst, L
Cancer Research null
Shuichan Xu et al.
The Journal of biological chemistry, 282(21), 15462-15470 (2007-04-06)
p27, an important cell cycle regulator, blocks the G(1)/S transition in cells by binding and inhibiting Cdk2/cyclin A and Cdk2/cyclin E complexes (Cdk2/E). Ubiquitination and subsequent degradation play a critical role in regulating the levels of p27 during cell cycle
Marco Salamina et al.
Journal of molecular biology, 433(5), 166795-166795 (2021-01-11)
The SCFSKP2 ubiquitin ligase relieves G1 checkpoint control of CDK-cyclin complexes by promoting p27KIP1 degradation. We describe reconstitution of stable complexes containing SKP1-SKP2 and CDK1-cyclin B or CDK2-cyclin A/E, mediated by the CDK regulatory subunit CKS1. We further show that
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