07-1213
Anti-IP3 Receptor 1 Antibody
serum, from rabbit
别名:
IP3 receptor isoform 1, Type 1 InsP3 receptor, Type 1 inositol 1,4,5-trisphosphate receptor, inositol 1,4,5-triphosphate receptor, type 1, spinocerebellar ataxia 15, spinocerebellar ataxia 16
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human
species reactivity (predicted by homology)
canine, rat
technique(s)
immunohistochemistry: suitable (paraffin), western blot: suitable
isotype
IgG
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
dog ... Itpr1(476548)
human ... ITPR1(3708)
mouse ... Itpr1(16438)
rat ... Itpr1(25262)
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General description
Approx. 300 kDa
IP3 Receptor 1 is an intracellular channel that when stimulated by inositol 1,4,5-triphosphate mediates the release of calcium from the endoplasmic reticulum. Defects within the gene ITPR1 cause a group of cerebellar disorders known as spinocerebellar ataxia type 15 (SCA15). This receptor is widely expressed in tissue.
Immunogen
Synthetic peptide from the N-terminal of human IP3 Receptor 1.
Application
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected IP3 Receptor 1 in mouse cerebellum tissue.
Research Category
Signaling
Signaling
Research Sub Category
Lipid Signaling
Lipid Signaling
This Anti-IP3 Receptor 1 Antibody is validated for use in IH(P), WB for the detection of IP3 Receptor 1.
Biochem/physiol Actions
The antibody reacts with the 300 kDa IP3 Receptor 1 protein.
Physical form
Rabbit serum. Liquid
Unpurified rabbit serum
Preparation Note
Maintain at -20°C in undiluted aliquots for up to 1 year date of receipt. Avoid repeated freeze/thaw cycles.
Analysis Note
Control
C2C12 cell lysates
C2C12 cell lysates
Evaluated by Western Blot in C2C12 cell lysates.
Western Blot Analysis: 1:500 dilution of this lot detected IP3 RECPT 1 on 10 ug of C2C12 lysates.
Western Blot Analysis: 1:500 dilution of this lot detected IP3 RECPT 1 on 10 ug of C2C12 lysates.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: AB9072
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Michael R Butler et al.
The Journal of biological chemistry, 292(27), 11189-11205 (2017-05-13)
Endoplasmic reticulum (ER) stress and mislocalization of improperly folded proteins have been shown to contribute to photoreceptor death in models of inherited retinal degenerative diseases. In particular, mice with cone cyclic nucleotide-gated (CNG) channel deficiency, a model for achromatopsia, display
Vera Khodzhaeva et al.
Frontiers in immunology, 12, 723683-723683 (2021-08-31)
Mitofusin 2 (MFN2) is a mitochondrial outer membrane GTPase, which modulates mitochondrial fusion and affects the interaction between endoplasmic reticulum and mitochondria. Here, we explored how MFN2 influences mitochondrial functions and inflammatory responses towards zymosan in primary human macrophages. A
Xiang Liu et al.
Molecular medicine reports, 14(6), 5435-5442 (2016-11-15)
Isoflurane is a commonly used inhaled anesthetic, which induces apoptosis of SH‑SY5Y cells in a dose‑ and time‑dependent manner; however, the underlying mechanisms remain unknown. The authors of the present study hypothesized that a mutation in β‑amyloid precursor protein (APP)
ER-mitochondria contacts and cholesterol metabolism are disrupted by disease-associated tau protein.
Leonora Szabo et al.
EMBO reports, 24(8), e57499-e57499 (2023-07-04)
Abnormal tau protein impairs mitochondrial function, including transport, dynamics, and bioenergetics. Mitochondria interact with the endoplasmic reticulum (ER) via mitochondria-associated ER membranes (MAMs), which coordinate and modulate many cellular functions, including mitochondrial cholesterol metabolism. Here, we show that abnormal tau
Manon Moulis et al.
Cells, 8(6) (2019-06-28)
Mitochondria-associated ER membranes (MAMs) are crucial for lipid transport and synthesis, calcium exchange, and mitochondrial functions, and they also act as signaling platforms. These contact sites also play a critical role in the decision between autophagy and apoptosis with far
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