生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
rat, mouse
制造商/商品名称
Upstate®
技术
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... KALRN(8997)
一般描述
190、115、370和420kDa亚型
免疫原
GST融合蛋白，对应于大鼠Kalirin的517-976位残基，用凝血酶切割以去除GST部分；简称JH2582
应用
抗Trio抗体是针对Trio的抗体，可用于IP、WB & IC。
研究子类别
G蛋白
细胞骨架信号转导
G蛋白
细胞骨架信号转导
研究类别
信号传导
信号传导
生化/生理作用
Kalirin；不与Trio发生交叉反应
外形
0.1M Tris-甘氨酸（pH 7.4），0.15M NaCl，0.05％叠氮化钠，然后添加甘油至30％
形式：纯化
蛋白A层析
制备说明
在-20°C下可保存2年
分析说明
通过免疫印迹对来自大鼠脑微粒体蛋白制剂的RIPA裂解液进行常规评估；可能需要较长的暴露时间
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
R E Mains et al.
The Journal of biological chemistry, 274(5), 2929-2937 (1999-01-23)
The production and regulated secretion of bioactive peptides require a series of lumenal enzymes to convert inactive precursors into bioactive peptides plus several cytosolic proteins to govern granule formation, maturation, translocation, and exocytosis. Peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme essential
Kalirin inhibition of inducible nitric-oxide synthase.
Ratovitski, E A, et al.
The Journal of Biological Chemistry, 274, 993-999 (1999)
P Penzes et al.
The Journal of biological chemistry, 275(9), 6395-6403 (2000-02-29)
Communication between membranes and the actin cytoskeleton is an important aspect of neuronal function. Regulators of actin cytoskeletal dynamics include the Rho-like small GTP-binding proteins and their exchange factors. Kalirin is a brain-specific protein, first identified through its interaction with
Deepak P Srivastava et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(34), 11864-11878 (2012-08-24)
Deficits in social and communication behaviors are common features of a number of neurodevelopmental disorders. However, the molecular and cellular substrates of these higher order brain functions are not well understood. Here we report that specific alterations in social and
Xiaoting Wang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(27), 11012-11022 (2013-07-05)
It is well established that behavioral sensitization to cocaine is accompanied by increased spine density and AMPA receptor (AMPAR) transmission in the nucleus accumbens (NAc), but two major questions remain unanswered. Are these adaptations mechanistically coupled? And, given that they
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