07-122
抗-Kalirin抗体
Upstate®, from rabbit
别名:
Anti-ARHGEF24, Anti-CHDS5, Anti-DUET, Anti-DUO, Anti-HAPIP, Anti-TRAD
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, IP, WB
Citations:
21
biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat, mouse
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KALRN(8997)
General description
190、115、370和420kDa亚型
Immunogen
GST融合蛋白，对应于大鼠Kalirin的517-976位残基，用凝血酶切割以去除GST部分；简称JH2582
Application
抗Trio抗体是针对Trio的抗体，可用于IP、WB & IC。
研究子类别
G蛋白
细胞骨架信号转导
G蛋白
细胞骨架信号转导
研究类别
信号传导
信号传导
Biochem/physiol Actions
Kalirin；不与Trio发生交叉反应
Physical form
0.1M Tris-甘氨酸（pH 7.4），0.15M NaCl，0.05％叠氮化钠，然后添加甘油至30％
形式：纯化
蛋白A层析
Preparation Note
在-20°C下可保存2年
Analysis Note
通过免疫印迹对来自大鼠脑微粒体蛋白制剂的RIPA裂解液进行常规评估；可能需要较长的暴露时间
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 1
R E Mains et al.
The Journal of biological chemistry, 274(5), 2929-2937 (1999-01-23)
The production and regulated secretion of bioactive peptides require a series of lumenal enzymes to convert inactive precursors into bioactive peptides plus several cytosolic proteins to govern granule formation, maturation, translocation, and exocytosis. Peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme essential
The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts.
Huang, S; Eleniste, PP; Wayakanon, K; Mandela, P; Eipper, BA; Mains, RE; Allen, MR; Bruzzaniti, A
Bone null
P Penzes et al.
The Journal of biological chemistry, 275(9), 6395-6403 (2000-02-29)
Communication between membranes and the actin cytoskeleton is an important aspect of neuronal function. Regulators of actin cytoskeletal dynamics include the Rho-like small GTP-binding proteins and their exchange factors. Kalirin is a brain-specific protein, first identified through its interaction with
Kalirin inhibition of inducible nitric-oxide synthase.
Ratovitski, E A, et al.
The Journal of Biological Chemistry, 274, 993-999 (1999)
Deepak P Srivastava et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(34), 11864-11878 (2012-08-24)
Deficits in social and communication behaviors are common features of a number of neurodevelopmental disorders. However, the molecular and cellular substrates of these higher order brain functions are not well understood. Here we report that specific alterations in social and
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