07-1375
抗磷酸化雄激素受体（Ser81）抗体
Upstate®, from rabbit
别名:
Anti-AIS, Anti-AR8, Anti-DHTR, Anti-HUMARA, Anti-HYSP1, Anti-KD, Anti-NR3C4, Anti-SBMA, Anti-SMAX1, Anti-TFM
产品名称
抗磷酸化雄激素受体（Ser81）抗体, Upstate®, from rabbit
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
dog (expected based only 1 amino acid difference), horse (expected based only 1 amino acid difference), primate (expected based only 1 amino acid difference), bovine (expected based only 1 amino acid difference)
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pSer81)
Quality Level
Gene Information
bovine ... Ar(280675)
dog ... Ar(403588)
human ... AR(367)
Analysis Note
对照
R1881（甲三烯醇酮）处理的LNCap裂解液
R1881（甲三烯醇酮）处理的LNCap裂解液
通过蛋白质印迹对R1881（甲雌三烯醇酮）处理的LNCap裂解液进行了常规评估
Application
抗磷酸雄激素受体（Ser81）抗体是一种针对磷酸雄激素受体（Ser81）的抗体，用于WB。
研究子类别
转录因子
转录因子
研究类别
信号传导
表观遗传学&核功能
信号传导
表观遗传学&核功能
Biochem/physiol Actions
仅在Ser81磷酸化后检测雄激素受体（AR）
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
110 kDa
X连锁雄激素受体（二氢睾酮受体；核受体亚家族3 C组成员4）是NR3配体依赖性转录因子家族的成员，其特征在于C末端的配体结合结构域、中央DNA结合结构域和N末端转录激活结构域。 雄激素受体被类固醇激素如睾酮和二氢睾酮激活。活化的雄激素受体从细胞质转移到细胞核，它们形成结合DNA的同型二聚体。雄激素受体与许多衔接子样蛋白结合，并作为复合物起作用，该复合物可以诱导或抑制转录，这取决于其相关蛋白是可能通过修饰染色质影响转录的共激活因子还是共抑制因子。共激活因子参与组蛋白乙酰化和转录激活，而共抑制因子参与组蛋白去乙酰化和转录抑制。雄激素受体对于确定性别和雄性特征很重要。缺陷的雄激素受体可能在Reifenstein综合征，肯尼迪病以及前列腺癌中起作用。
Immunogen
对应于人雄激素受体Ser81及其周围氨基酸的KLH结合合成肽。
Physical form
纯化的兔多克隆抗体，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
Preparation Note
自收到之日起在2-8°C可稳定保存1年。
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。避免反复冻融，其可能会破坏IgG并影响产品性能。
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。避免反复冻融，其可能会破坏IgG并影响产品性能。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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