07-1491
Anti-Calcineurin pan A Antibody
from rabbit, purified by affinity chromatography
别名:
CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform, calcineurin A alpha, protein phosphatase 3 (formerly 2B), catalytic subunit,
alpha isoform, protein phosphatase 3 (formerly 2B), catalytic subunit,
alp
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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
conjugate
Clone:
polyclonal
Application:
WB
Citations:
14
biological source
rabbit
conjugate
conjugate
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
liquid
purified by
affinity chromatography
species reactivity
human, rat, mouse
species reactivity (predicted by homology)
mammals (based on 100% sequence homology)
technique(s)
western blot: suitable
immunogen sequence
KLH-conjugated synthetic peptide corresponding to Calcineurin.
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
General description
Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin′s multifunctional capabilities in the regulation of calcium signaling.
~58 kDa
Immunogen
KLH-conjugated synthetic peptide corresponding to Calcineurin.
Application
Detect Calcineurin pan A using this Anti-Calcineurin pan A Antibody validated for use in WB.
Research Category
Signaling
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
GPCR, cAMP/cGMP & Calcium Signaling
Biochem/physiol Actions
This antibody recognizes both the Aα and Aβ, the major catalytic subunit gene isoforms of calcineurin in most tissues; may also react with the testis form, Aγ. This antibody has very high sensitivity and specificity, which allow detection of calcineurin in tissues where expression is low, such as lymphoid tissue. Reacts with calcineurin of all mammalian species.
Physical form
Affinity purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative.
Preparation Note
Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will
remain unfrozen.
remain unfrozen.
Analysis Note
Control
Mouse brain lysate
Mouse brain lysate
Evaluated by Western Blot in Mouse brain lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate.
Other Notes
Replaces: AB1695
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Kelly M Grimes et al.
Frontiers in physiology, 14, 1054169-1054169 (2023-02-04)
Introduction: The ribosomal protein L3-like (RPL3L) is a heart and skeletal muscle-specific ribosomal protein and paralogue of the more ubiquitously expressed RPL3 protein. Mutations in the human RPL3L gene are linked to childhood cardiomyopathy and age-related atrial fibrillation, yet the
Bastian Bruns et al.
Nature cardiovascular research, 2(7), 645-655 (2023-07-01)
Takotsubo syndrome (TTS) is an acute heart failure syndrome that mimics the symptoms of acute myocardial infarction and is often preceded by emotional and/or physical stress. There is currently no treatment for TTS. Here we show that injection of 2.5 mg kg-1
Divergent effects of GLP-1 analogs exendin-4 and exendin-9 on the expression of myosin heavy chain isoforms in C2C12 myotubes.
Lina Wang,Feng Guo,Shi Wei,Ruqian Zhao
Peptides null
Val Andrew Fajardo et al.
Brain and behavior, 6(6), e00470-e00470 (2016-05-03)
Phospholamban (PLN) and sarcolipin (SLN) are small inhibitory proteins that regulate the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) pump. Previous work from our laboratory revealed that in the soleus and gluteus minimus muscles of mice overexpressing PLN (Pln (OE)), SERCA function was
Virginie Joris et al.
Arteriosclerosis, thrombosis, and vascular biology, 38(10), 2345-2357 (2018-07-07)
Objective- Members of the microRNA (miR)-199a family, namely miR-199a-5p and miR-199a-3p, have been recently identified as potential regulators of cardiac homeostasis. Also, upregulation of miR-199a expression in cardiomyocytes was reported to influence endothelial cells. Whether miR-199a is expressed by endothelial
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