跳转至内容
Merck
CN

07-1735

抗-HuR抗体

from rabbit, purified by affinity chromatography

别名:

ELAV-like 1, Hu antigen R, Hu-antigen R, embryonic lethal, abnormal vision, drosophila, homolog-like 1

登录 查看组织和合同定价。

选择尺寸

关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunofluorescence
western blot
Species reactivity:
human, rat, mouse
Citations:
5
Technique(s):
immunofluorescence: suitable
western blot: suitable
Uniprot accession no.:
Q15717

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

抗-HuR抗体, from rabbit, purified by affinity chromatography

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, rat, mouse

technique(s)

immunofluorescence: suitable
western blot: suitable

NCBI accession no.

NP_001410.2

UniProt accession no.

Q15717

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ELAVL1(1994)
mouse ... Elavl1(15568)
rat ... Elavl1(363854)

相关类别

Analysis Note

对照
Jurkat细胞裂解液
蛋白质印迹分析：
该抗体在Jurkat细胞裂解液中以1:500-1:1,000的稀释度检测到HuR，该裂解液通过SDS-PAGE分离并转移至PVDF。

Application

使用在WB，IF中验证的抗HuR抗体（兔多克隆抗体）检测HuR，也称为ELAV样1，Hu抗原R。
免疫荧光ICC分析：
研究子类别
胰岛素/能量信号传导

RNA结合蛋白（RBP）
研究类别
信号传导

Biochem/physiol Actions

其他物种尚未经过测试。
检测HuR

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

36 kDa
HuR（Hu-抗原R，ELAV样蛋白1，ELAV1）是一种RNA结合蛋白，包含3个RNA结合域。 已知可以结合mRNA的富含AU的元件。 它通过破坏其mRNA的稳定性来调节基因表达。已知它在某些癌症（例如乳腺癌和胃癌）中被上调。 它的一些靶标包括cFos，IL-3和BRCA1 mRNA。HuR还被证明参与某些细胞类型中VEFG-A和NFkB表达的调节。它的激活和积累也与许多能量信号分子有关，例如PI3K/Akt途径和AMPK。

Immunogen

合成肽对应于人HuR的N末端。
表位：N末端

Other Notes

替代：AB5831

Physical form

亲和纯化的多克隆沉淀在硫酸铵中。
在不含防腐剂的50%饱和硫酸铵和PBS溶液中的兔多克隆沉淀抗体

Preparation Note

自收到之日起，在-20°C条件下可稳定保存1年。
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。

未找到合适的产品？  

试试我们的产品选型工具.

存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Identification of Novel Stress Granule Components That Are Involved in Nuclear Transport.
Mahboubi, H; Seganathy, E; Kong, D; Stochaj, U
Testing null
Harsha Raheja et al.
PLoS pathogens, 19(8), e1011552-e1011552 (2023-08-04)
Host protein HuR translocation from nucleus to cytoplasm following infection is crucial for the life cycle of several RNA viruses including hepatitis C virus (HCV), a major causative agent of hepatocellular carcinoma. HuR assists the assembly of replication-complex on the
Weirui Ma et al.
eLife, 10 (2021-03-03)
Liquid-like condensates have been thought to be sphere-like. Recently, various condensates with filamentous morphology have been observed in cells. One such condensate is the TIS granule network that shares a large surface area with the rough endoplasmic reticulum and is
Binyamin D Berkovits et al.
Nature, 522(7556), 363-367 (2015-04-22)
About half of human genes use alternative cleavage and polyadenylation (ApA) to generate messenger RNA transcripts that differ in the length of their 3' untranslated regions (3' UTRs) while producing the same protein. Here we show in human cell lines
Weirui Ma et al.
Cell, 175(6), 1492-1506 (2018-11-20)
Approximately half of human genes generate mRNAs with alternative 3' untranslated regions (3'UTRs). Through 3'UTR-mediated protein-protein interactions, alternative 3'UTRs enable multi-functionality of proteins with identical amino acid sequence. While studying how information on protein features is transferred from 3'UTRs to

相关内容

RNA-Binding Protein Immunoprecipitation

All eukaryotic organisms require tight regulation of gene expression for complex processes such as development, differentiation, cell specification, and responses to environmental stimuli. Many genes are regulated post-transcriptionally, in addition to transcriptional mechanisms of gene regulation. RNA-binding proteins (RBPs) are essential for post-transcriptional gene regulation, linking transcription and translation in many processes including transcription, splicing, export, rate of translation and turnover. In all of these events, RBPs coordinate regulation of the amount of protein produced from mRNA transcripts.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持