260kDa

The Notch protein family is a group of highly conserved proteins important in the determination of cell fate and maintenance of progenitors in many developmental systems. This family of proteins function both as membrane cell receptors and as transcription factors. Activation of Notch by cell-cell interactions causes a transcription inhibitory effect that enables inhibition of differentiation in some cells but not in others. As a consequence, some cells adopt a particular fate while other progenitors remain uncommitted. The Notch protein is important in cell fate during myogenesis, neurogenesis, oogenesis, and wing and eye development in Drosophila. In mammals, four Notch genes were identified (Notch 1-4) that are expressed in a wide variety of cells and play a crucial role in differentiation and development.

N-terminal GST fusion protein corresponding to residues 381-853 of rat Notch1

Anti-Notch1 Antibody, extracellular domain is a high quality Rabbit Polyclonal Antibody for the detection of Notch1 & has been validated in WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

Used in mouse in the following publication: Gulino, R., et al, European Journal of Neuroscience, Vol. 31, pp. 1423–1434, 2010.

Notch1

Protein A chromatography

Format: Purified

Protein A purified immunoglobulin presented in 0.1M Tris-Glycine, 0.15M NaCl, and 0.05% Sodium Azide, pH 7.4

Stable for 1 year at 2-8°C from date of receipt.

Control
L/N17 transfected Notch1 cell lysate

Routinely evaluated by immunoblot on RIPA lysates from L/N17 rat Notch1 transfected fibroblast cells

Replaces: 04-1046

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.