07-2271
Anti-Serine/threonine-protein kinase 39 Antibody
from rabbit, purified by affinity chromatography
别名:
serine threonine kinase 39, proline-alanine-rich STE20-related kinase, Serine/threonine-protein kinase 39, serine threonine kinase 39 (STE20/SPS1 homolog, yeast), Ste-20-related kinase, Ste20-like protein kinase, small intestine SPAK-like kinase, STE20/S
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关于此项目
eCl@ss:
32160702
UNSPSC Code:
12352203
Clone:
polyclonal
Species reactivity:
human
Application:
WB
Citations:
1
biological source
rabbit
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... STK39(27347)
General description
STE20/SPS-1 related proline alanine-rich kinase (SPAK), or commonly known as Serine/threonine-protein kinase 39, is a member of the SPS1 subfamily of STE20 kinases. Serine/threonine-protein kinase 39 is also very highly conserved between species and has been shown to activate the p38 pathways. Serine/threonine-protein kinase 39 also has a caspase cleavage site and these two functions may mean that Serine/threonine-protein kinase 39 plays a role in stress-activated signaling. Serine/threonine-protein kinase 39 expression is up-regulated by androgens in LNCaP human prostate cancer cells and regulated and phosphorylated by WNK1, which controls the stress signaling pathway. It is activated by WNK4 and then has the ability to stimulate the Na-K-2Cl cotransporter, the inactive version does not posses this ability. Recent research has also made a connection between Serine/threonine-protein kinase 39 and regulation of blood pressure.
~60 kDa observed
Immunogen
GST-tagged recombinant protein corresponding to human Serine/threonine-protein kinase 39.
Application
This Serine/threonine-protein kinase 39 antibody is validated for use in WB for the detection of the Serine/threonine-protein kinase 39 protein.
Biochem/physiol Actions
Other homologies: Mouse (95% sequence homology). Rat (94% sequence homology).
Analysis Note
Evaluated by Western Blot in HEK293 cell lysate.
Western Blot Analysis: 1:900 dilution of this antibody detected Serine/threonine-protein kinase 39 on 10 µg of HEK293 cell lysate.
Western Blot Analysis: 1:900 dilution of this antibody detected Serine/threonine-protein kinase 39 on 10 µg of HEK293 cell lysate.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Eva Dizin et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(2), 2408-2424 (2020-01-08)
The mechanism of sodium retention and its location in kidney tubules may vary with time in nephrotic syndrome (NS). We studied the mechanisms of sodium retention in transgenic POD-ATTAC mice, which display an inducible podocyte-specific apoptosis. At day 2 after
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