07-2271
Anti-Serine/threonine-protein kinase 39 Antibody
from rabbit, purified by affinity chromatography
别名:
serine threonine kinase 39, proline-alanine-rich STE20-related kinase, Serine/threonine-protein kinase 39, serine threonine kinase 39 (STE20/SPS1 homolog, yeast), Ste-20-related kinase, Ste20-like protein kinase, small intestine SPAK-like kinase, STE20/S
生物来源
rabbit
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... STK39(27347)
一般描述
STE20/SPS-1 related proline alanine-rich kinase (SPAK), or commonly known as Serine/threonine-protein kinase 39, is a member of the SPS1 subfamily of STE20 kinases. Serine/threonine-protein kinase 39 is also very highly conserved between species and has been shown to activate the p38 pathways. Serine/threonine-protein kinase 39 also has a caspase cleavage site and these two functions may mean that Serine/threonine-protein kinase 39 plays a role in stress-activated signaling. Serine/threonine-protein kinase 39 expression is up-regulated by androgens in LNCaP human prostate cancer cells and regulated and phosphorylated by WNK1, which controls the stress signaling pathway. It is activated by WNK4 and then has the ability to stimulate the Na-K-2Cl cotransporter, the inactive version does not posses this ability. Recent research has also made a connection between Serine/threonine-protein kinase 39 and regulation of blood pressure.
~60 kDa observed
免疫原
GST-tagged recombinant protein corresponding to human Serine/threonine-protein kinase 39.
应用
This Serine/threonine-protein kinase 39 antibody is validated for use in WB for the detection of the Serine/threonine-protein kinase 39 protein.
生化/生理作用
Other homologies: Mouse (95% sequence homology). Rat (94% sequence homology).
分析说明
Evaluated by Western Blot in HEK293 cell lysate.
Western Blot Analysis: 1:900 dilution of this antibody detected Serine/threonine-protein kinase 39 on 10 µg of HEK293 cell lysate.
Western Blot Analysis: 1:900 dilution of this antibody detected Serine/threonine-protein kinase 39 on 10 µg of HEK293 cell lysate.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Eva Dizin et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(2), 2408-2424 (2020-01-08)
The mechanism of sodium retention and its location in kidney tubules may vary with time in nephrotic syndrome (NS). We studied the mechanisms of sodium retention in transgenic POD-ATTAC mice, which display an inducible podocyte-specific apoptosis. At day 2 after
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