生物来源
rabbit
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
human
制造商/商品名称
Upstate®
技术
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
acetylation (Lys5,Lys12,Lys15,Lys20)
基因信息
human ... H2BC1(255626)
一般描述
15 kDa
免疫原
其中在人组蛋白H2B的5、12、15和20残基处有一个乙酰化赖氨酸的合成肽
应用
使用抗乙酰化组蛋白H2B抗体（兔多克隆抗体）检测乙酰化组蛋白H2B（也称为组蛋白H2B），经证明可在WB起作用。
研究子类别
组蛋白
组蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
生化/生理作用
乙酰化组蛋白H2B
外形
0.1M Tris-甘氨酸，pH 7.4，0.15M NaCl，0.05％ 叠氮化钠，然后添加甘油至30％
形式：纯化
蛋白A层析
制备说明
在-20°C下可保存2年
分析说明
通过免疫印迹对经丁酸钠处理的HeLa细胞的酸提取蛋白进行了常规评估
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus.
Bousiges, O; Vasconcelos, AP; Neidl, R; Cosquer, B; Herbeaux, K; Panteleeva, I; Loeffler et al.
Neuropsychopharmacology null
Kelly L West et al.
Immunity, 23(2), 203-212 (2005-08-23)
V(D)J recombination is a tightly controlled process of somatic recombination whose regulation is mediated in part by chromatin structure. Here, we report that RAG2 binds directly to the core histone proteins. The interaction with histones is observed in developing lymphocytes
Estelle Schueller et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 33, 101-116 (2020-02-15)
Memory impairment is the main feature of Alzheimer's disease (AD). Initial impairments originate in the temporal lobe area and propagate throughout the brain in a sequential manner. Epigenetic mechanisms, especially histone acetylation, regulate plasticity and memory processes. These may be
Snehajyoti Chatterjee et al.
EMBO molecular medicine, 10(11) (2018-10-03)
Chromatin acetylation, a critical regulator of synaptic plasticity and memory processes, is thought to be altered in neurodegenerative diseases. Here, we demonstrate that spatial memory and plasticity (LTD, dendritic spine formation) deficits can be restored in a mouse model of
Lucie Crouzier et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 39, 29-45 (2020-09-08)
The sigma-1 receptor (S1R) is a membrane-associated protein expressed in neurons and glia at mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs). S1R interacts with different partners to regulate cellular responses, including ER stress, mitochondrial physiology and Ca2+ fluxes. S1R shapes cellular
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