产品名称
Anti-Akt3/PKBγ Antibody, Upstate®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AKT3(10000)
Analysis Note
Control
IGF-I stimulated HEK293 cell lysates
IGF-I stimulated HEK293 cell lysates
routinely evaluated by immunoprecipitating active Akt3/PKBγ from IGF-I stimulated HEK293 cell lysates.
Application
Anti-Akt3/PKBγ Antibody is an antibody against Akt3/PKBγ for use in IP & WB.
Biochem/physiol Actions
Recognizes Akt3/PKBγ.
General description
~60 kDa
Immunogen
peptide corresponding to amino acids 119-131 of human Akt3/PKBgamma
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: AB3136
Physical form
Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Demetris C Iacovides et al.
Molecular & cellular proteomics : MCP, 12(11), 3210-3220 (2013-08-10)
Breast cancer subtype-specific molecular variations can dramatically affect patient responses to existing therapies. It is thought that differentially phosphorylated protein isoforms might be a useful prognostic biomarker of drug response in the clinic. However, the accurate detection and quantitative analysis
Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions
Katome, T., et al
The Journal of Biological Chemistry, 278, 28312-28323 (2003)
Anna Joy et al.
Journal of neuro-oncology, 130(1), 43-52 (2016-10-21)
The growth factor receptor/PI3K/AKT pathway is an important drug target in many cancers including Glioblastoma. AKT, a key node in the pathway, has 3 isoforms, AKT1, AKT2 and AKT3. Here we investigate their role in GBM. We find each activated
Conrad P Hodgkinson et al.
Biochemistry, 41(32), 10351-10359 (2002-08-07)
Protein kinase B (PKB), also known as Akt, is a serine/threonine protein kinase controlled by insulin, various growth factors, and phosphatidylinositol 3-kinase. Full activation of the PKB enzyme requires phosphorylation of a threonine in the activation loop and a serine
François Fabi et al.
PloS one, 12(5), e0177387-e0177387 (2017-05-06)
Infertility is constantly increasing in Canada, where 16% of Canadian couples are experiencing difficulty conceiving. It is thought that infertility can emanate from the dysregulated communication between the embryo and the maternal endometrium. In order to allow for this window
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