07-442-AF488
Anti-trimethyl Histone H3 (Lys9) Antibody, Alexa Fluor™ 488 Conjugate
0.5 mg/mL, from rabbit
别名:
Histone H3.1t, H3/t, H3t, H3/g
产品名称
Anti-trimethyl Histone H3 (Lys9) Antibody, Alexa Fluor™ 488 Conjugate, 0.5 mg/mL, from rabbit
biological source
rabbit
conjugate
ALEXA FLUOR™ 488
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
species reactivity (predicted by homology)
chicken (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology)
concentration
0.5 mg/mL
technique(s)
immunocytochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
trimethylation (Lys9)
Quality Level
Gene Information
human ... H3C1(8350)
mouse ... H3C1(360198)
rat ... H3C1(679994)
Physical form
Protein A purified
Purified rabbit conjugate in buffer containing PBS with 15 mg/ml BSA and 0.1% Sodium Azide.
General description
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. Histone proteins are highly post-translationally modified, and Histone H3 is the most extensively modified of the five histones. Histone H3 sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Di- and tri-methylation of histone H3 are gene silencing marks, while removal of these marks by the demethylase genes Jmjd1a and Jmjd2c leads to gene activation. This product is a conjugated version of Cat. No. 07-442.
~17 kDa observed (Refer to Cat. No. 07-442)
Analysis Note
Evaluated by Immunocytochemistry in HeLa cell lysate.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected trimethyl Histone H3 (Lys9) in HeLa cells.
Alexa Fluor™ is a registered trademark of Life Technologies.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected trimethyl Histone H3 (Lys9) in HeLa cells.
Alexa Fluor™ is a registered trademark of Life Technologies.
Application
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
This Anti-trimethyl Histone H3 (Lys9) Antibody, Alexa Fluor™ 488 Conjugate is validated for use in ICC for the detection of trimethyl Histone H3 (Lys9).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
Linear peptide corresponding to Histone H3 trimethylated at Lys9.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Gayani Batugedara et al.
Microbial genomics, 6(2) (2020-02-06)
Proteins interacting with DNA are fundamental for mediating processes such as gene expression, DNA replication and maintenance of genome integrity. Accumulating evidence suggests that the chromatin of apicomplexan parasites, such as Plasmodium falciparum, is highly organized, and this structure provides
Maegan L Capitano et al.
The Journal of clinical investigation, 129(6), 2555-2570 (2019-05-21)
The nuclear protein DEK is an endogenous DNA-binding chromatin factor regulating hematopoiesis. DEK is one of only 2 known secreted nuclear chromatin factors, but whether and how extracellular DEK regulates hematopoiesis is not known. We demonstrated that extracellular DEK greatly
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