07-472
Anti-PTPα Antibody
Upstate®, from rabbit
别名:
Anti-HEPTP, Anti-HPTPA, Anti-HPTPalpha, Anti-LRP, Anti-PTPA, Anti-PTPRL2, Anti-R-PTP-alpha, Anti-RPTPA
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
14
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human, rat
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PTPRA(5786)
mouse ... Ptpra(19262)
rat ... Ptpra(25167)
General description
130kDa
Immunogen
N-terminal GST-tagged fusion protein corresponding to residues 505-793 of human PTP alpha (complete D2 catalytic domain).
Application
Anti-PTPα Antibody detects level of PTPα & has been published & validated for use in WB.
Research Category
Signaling
Signaling
Research Sub Category
Kinases & Phosphatases
Kinases & Phosphatases
Biochem/physiol Actions
PTP alpha isoform
Physical form
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
ImmunoAffinity Purified
Preparation Note
1 year at -20°C
Analysis Note
Routinely evaluated by immunoblot in in NIH 3T3 cell lysates.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
A Petrone et al.
Journal of cell science, 113 ( Pt 13), 2345-2354 (2000-06-15)
Transmembrane (receptor) tyrosine phosphatases are intimately involved in responses to cell-cell and cell-matrix contact. Several important issues regarding the targets and regulation of this protein family are now emerging. For example, these phosphatases exhibit complex interactions with signaling pathways involving
Two mechanisms activate PTPalpha during mitosis.
Zheng, X M and Shalloway, D
The Embo Journal, 20, 6037-6049 (2001)
Christine R Keenan et al.
Genome research, 34(4), 556-571 (2024-05-09)
H3K9me3-dependent heterochromatin is critical for the silencing of repeat-rich pericentromeric regions and also has key roles in repressing lineage-inappropriate protein-coding genes in differentiation and development. Here, we investigate the molecular consequences of heterochromatin loss in cells deficient in both SUV39H1
Chan Zhou et al.
Genome medicine, 8(1), 31-31 (2016-03-24)
Hepatic fibrosis is the underlying cause of cirrhosis and liver failure in nearly every form of chronic liver disease, and hepatic stellate cells (HSCs) are the primary cell type responsible for fibrosis. Long noncoding RNAs (lncRNAs) are increasingly recognized as
Xin-Min Zheng et al.
The Journal of biological chemistry, 277(24), 21922-21929 (2002-03-30)
During mitosis, the catalytic activity of protein-tyrosine phosphatase (PTP) alpha is enhanced, and its inhibitory binding to Grb2, which specifically blocks Src dephosphorylation, is decreased. These effects act synergistically to activate Src in mitosis. We show here that these effects
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