生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
human, rat
制造商/商品名称
Upstate®
技术
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
unmodified
基因信息
human ... SPRY2(10253)
一般描述
35-40 kDa
免疫原
Peptide corresponding to amino acids 26-39 of human SPROUTY2
应用
Detect Spry2 using this Anti-Spry2 Antibody validated for use in WB.
Research Category
Signaling
Signaling
Research Sub Category
Growth Factors & Receptors
Kinases & Phosphatases
Growth Factors & Receptors
Kinases & Phosphatases
生化/生理作用
Recognizes SPROUTY2.
外形
Protein A purified
Format: Purified
Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
制备说明
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
分析说明
Control
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.
routinely evaluated by immunoblot in in RIPA lysates from HeLa and 3T3/A31
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
N Hacohen et al.
Cell, 92(2), 253-263 (1998-02-11)
Antagonists of several growth factor signaling pathways play important roles in developmental patterning by limiting the range of the cognate inducer. Here, we describe an antagonist of FGF signaling that patterns apical branching of the Drosophila airways. In wild-type embryos
Permeen Yusoff et al.
The Journal of biological chemistry, 277(5), 3195-3201 (2001-11-08)
Several genetic studies in Drosophila have shown that the dSprouty (dSpry) protein inhibits the Ras/mitogen-activated protein (MAP) kinase pathway induced by various activated receptor tyrosine kinase receptors, most notably those of the epidermal growth factor receptor (EGFR) and fibroblast growth
Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma.
Fritzsche, S; Kenzelmann, M; Hoffmann, MJ; Muller, M; Engers, R; Grone, HJ; Schulz, WA
Endocrine-Related Cancer null
Weimin Liu et al.
The Journal of allergy and clinical immunology, 121(4), 893-902 (2008-04-09)
Many airway cells manifest signs of chronic activation in asthma. The mechanism of this chronic activation is unknown. We sought to study the activation of the mitogen-activated protein kinase (MAPK) signaling pathway in airway cells. Endobronchial biopsy specimens from patients
Yasuhiro Hasegawa et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 49(3), 314-323 (2018-08-30)
Bile acid biosynthesis is strictly regulated under physiological conditions. The expression of fibroblast growth factor (FGF) 19 is induced when bile acids bind to the farnesoid X receptor in the intestinal epithelium. Fibroblast growth factor 19 is then transported by
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