biological source
rabbit
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... SUV39H1(6839)
General description
48kDa
Immunogen
Peptide (C-QVDPVDMESTRMDSNFGLAGLPGSP) corresponding to amino acids 368-392 of mouse suppressor of variegation 3-9 homolog 1 (SUV39H1).
Application
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
Use Anti-SUV39H1 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect SUV39H1 also known as KMT1A, Histone H3-K9 Methyltransferase 1.
Biochem/physiol Actions
SUV39H1
Physical form
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide, pH 7.4.
Format: Purified
Protein A purified
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
For maximum recovery of product, centrifuge the vial prior to removing the cap.
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Analysis Note
Routinely evaluated by immunoblot in U20S cells lysed in RIPA with 0.1% SDS and sonicated.
Other Notes
Replaces: MABE552
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
Hakima Yahi et al.
The Journal of biological chemistry, 283(35), 23692-23700 (2008-07-05)
Mechanisms of transcriptional repression are important during cell differentiation. Mammalian heterochromatin protein 1 isoforms HP1alpha, HP1beta, and HP1gamma play important roles in the regulation of chromatin structure and function. We explored the possibility of different roles for the three HP1
S J Nielsen et al.
Nature, 412(6846), 561-565 (2001-08-03)
In eukaryotic cells the histone methylase SUV39H1 and the methyl-lysine binding protein HP1 functionally interact to repress transcription at heterochromatic sites. Lysine 9 of histone H3 is methylated by SUV39H1 (ref. 2), creating a binding site for the chromo domain
Imtiyaz Yaseen et al.
The EMBO journal, 37(2), 183-200 (2017-11-25)
Host cell defense against an invading pathogen depends upon various multifactorial mechanisms, several of which remain undiscovered. Here, we report a novel defense mechanism against mycobacterial infection that utilizes the histone methyltransferase, SUV39H1. Normally, a part of the host chromatin
Rajeev Mishra et al.
3 Biotech, 12(11), 290-290 (2022-10-25)
Telomere length is primarily controlled by the enzyme telomerase, but being chromatin structures, telomeres undergo epigenetic regulation for their maintenance and function. Altered telomere length among cancer cells combined with shorter telomere length in cancer-associated stromal cells, strongly implicated with
Marta García-Cao et al.
Nature genetics, 36(1), 94-99 (2004-01-01)
Telomeres are capping structures at the ends of eukaryotic chromosomes composed of TTAGGG repeats bound to an array of specialized proteins. Telomeres are heterochromatic regions. Yeast and flies with defects in activities that modify the state of chromatin also have
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