07-667
Anti-Amyloid Precursor Protein (APP) Antibody
UPSTATE®, rabbit polyclonal
别名:
Anti-AAA, Anti-ABPP, Anti-AD1, Anti-APPI, Anti-CTFgamma, Anti-CVAP, Anti-PN-II, Anti-PN2, Anti-alpha-sAPP, Anti-preA4
产品名称
抗APP抗体, Upstate®, from rabbit
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human, rat, mouse
种属反应性(根据同源性预测)
chimpanzee (based on 100% sequence homology), primate (based on 100% sequence homology)
制造商/商品名称
Upstate®
技术
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型
IgG
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... APP(351)
一般描述
110kDa
免疫原
与人淀粉样前体蛋白(APP)的44-61位氨基酸对应的合成肽
应用
抗APP抗体可检测APP水平&,已发表 &并经过验证可用于IP &WB。
研究子类别
泛素 & 泛素代谢
神经退行性疾病
泛素 & 泛素代谢
神经退行性疾病
研究类别
神经科学
神经科学
生化/生理作用
APP
外形
免疫亲和纯化
纯化的兔多克隆抗体,溶于含有0.1 M Tris-甘氨酸(pH 7.4)、150 mM NaCl和0.05%叠氮化钠的缓冲液中。
制备说明
自收到之日起,在2-8°C条件下可稳定保存1年。
分析说明
已通过免疫印迹进行常规评估。
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production.
Wilson, Christina A, et al.
Journal of Neuroscience Research, 74, 361-369 (2003)
Structure and function of amyloid in Alzheimer's disease.
Morgan, Carlos, et al.
Progress in Neurobiology, 74, 323-349 (2004)
CSF markers for Alzheimer's disease: total tau, phospho-tau and Abeta42.
Andreasen, Niels, et al.
The World Journal of Biological Psychiatry : The Official Journal of the World Federation of Societies of Biological Psychiatry, 4, 147-155 (2003)
Role of acyl-coenzyme a: cholesterol acyltransferase activity in the processing of the amyloid precursor protein.
Puglielli, Luigi, et al.
Journal of Molecular Neuroscience, 24, 93-96 (2004)
Xia Jiang et al.
Neurochemical research, 44(12), 2708-2722 (2019-10-16)
Macroautophagy, a sole pathway for dysfunctional organelles or aggregated proteins turnover, has been implicated in the early development of Alzheimer's disease (AD). Previous studies have found that reversal of autophagy dysfunction in APP transgenic mice ameliorates amyloid pathologies. Icariin (ICA)
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