产品名称
Anti-phospho-Abl (Tyr245) Antibody, Upstate®, from rabbit
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
ELISA: suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pTyr245)
Quality Level
Gene Information
human ... ABI1(10006)
mouse ... Abi1(11308)
rat ... Abi1(79249)
Application
Research Category
Signaling
Signaling
Anti-phospho-Abl (Tyr245) Antibody is an antibody against phospho-Abl (Tyr245) for use in ELISA & WB.
Research Sub Category
Cytoskeletal Signaling
General Post-translation Modification
Cytoskeletal Signaling
General Post-translation Modification
Analysis Note
Routinely evaluated by immunoblot.
Biochem/physiol Actions
Other species have not been tested.
Recognizes both Abl and BCR-Abl when phosphorylated on tyrosine residue corresponding to Tyr245 in Abl.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
145 kDa (210 kDa for BCR-Abl)
Immunogen
KLH-conjugated peptide corresponding to amino acid region encompassing human c-Abl Tyr245.
Physical form
ImmunoAffinity Purified
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
A common phosphotyrosine signature for the Bcr-Abl kinase
Goss, Valerie L, et al
Blood, 107, 4888-4897 (2006)
Phosphoproteomic analysis of AML cell lines identifies leukemic oncogenes
Walters, Denise K, et al
Leukemia Research, 30, 1097-1104 (2006)
Phosphotyrosine mapping in Bcr/Abl oncoprotein using phosphotyrosine-specific immonium ion scanning
Steen, Hanno, et al
Molecular and Cellular Proteomics, 2, 138-145 (2003)
Anna Stenqvist et al.
Neuroscience letters, 435(1), 11-16 (2008-03-21)
Ret is a receptor tyrosine kinase for the GDNF family of ligands and plays important roles during nervous system development for cell proliferation, cell migration and neurite growth. Signaling initiated from intracellular tyrosine 1062, by recruitment of several different phosphotyrosine
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