07-788
Anti-phospho-Abl (Tyr412) Antibody
Upstate®, from rabbit
别名:
ABL1, JTK7, c-ABL, p150, v-abl, v-abl Abelson murine leukemia viral oncogene homolog 1
产品名称
Anti-phospho-Abl (Tyr412) Antibody, Upstate®, from rabbit
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
ELISA: suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pTyr412)
Quality Level
Gene Information
human ... ABI1(10006)
mouse ... Abi1(11308)
rat ... Abi1(79249)
Analysis Note
Routinely evaluated by immunoblot.
Application
Research Category
Signaling
Signaling
Research Sub Category
Cytoskeletal Signaling
General Post-translation Modification
Cytoskeletal Signaling
General Post-translation Modification
This Anti-phospho-Abl (Tyr412) Antibody is validated for use in ELISA, WB for the detection of phospho-Abl (Tyr412).
Biochem/physiol Actions
Other species have not been tested.
Recognizes both Abl and BCR-Abl when phosphorylated on tyrosine residue corresponding to Tyr412 in Abl.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
145 kDa
Immunogen
KLH-conjugated peptide corresponding to amino acid region encompassing human c-Abl Tyr412.
Physical form
ImmunoAffinity Purified
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
Wenjing Tao et al.
The Journal of biological chemistry, 289(31), 21463-21472 (2014-06-14)
Jak2 is involved in cytokine growth factor-stimulated signal transduction, but the mechanism of its activation is largely unknown. Here, we investigated Jak2 activation in a normal hematopoietic cell line, 32D mouse myeloid cells. The bimolecular fluorescence complementation studies showed that
Phosphoproteomic analysis of AML cell lines identifies leukemic oncogenes
Walters, Denise K, et al
Leukemia Research, 30, 1097-1104 (2006)
Jia Hu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 30(2), 450-461 (2023-11-09)
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Phosphotyrosine mapping in Bcr/Abl oncoprotein using phosphotyrosine-specific immonium ion scanning
Steen, Hanno, et al
Molecular and Cellular Proteomics, 2, 138-145 (2003)
Tamara Marín et al.
Frontiers in cell and developmental biology, 10, 844297-844297 (2022-04-12)
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