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Merck
CN

07-789

Sigma-Aldrich

Anti-phospho-AKT (Thr34) Antibody

Upstate®, from rabbit

别名:

Akt1, PKB, PRKBA, RAC, RAC-ALPHA

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关于此项目

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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生物来源

rabbit

质量水平

抗体形式

affinity purified immunoglobulin

抗体产品类型

primary antibodies

克隆

polyclonal

纯化方式

affinity chromatography

种属反应性

human

制造商/商品名称

Upstate®

技术

western blot: suitable

同位素/亚型

IgG

UniProt登记号

运输

dry ice

靶向翻译后修饰

phosphorylation (pThr34)

基因信息

human ... AKT1(207)

一般描述

60 kDa

免疫原

KLH conjugated peptide corresponding to amino acid region encompassing the human phospho-AKT (Thr34); Sequence highly conserved in mouse and rat.

应用

Anti-phospho-AKT (Thr34) Antibody detects level of phospho-AKT (Thr34) & has been published & validated for use in WB.
Research Category
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling

General Post-translation Modification

生化/生理作用

Predicted to cross react with Mouse and Rat due to high sequence homology, but have not been tested.
Recognizes phospho-AKT (Thr34)

外形

ImmunoAffinity Purified
100 μL of epitope specific affinity purified rabbit polyclonal IgG in 50% affinity storage buffer (PBS containing 1.0 mg/mL BSA and 0.05% sodium azide) and 50% glycerol.

制备说明

Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

分析说明

Routinely evaluated by immunoblot.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

WGK 2


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访问文档库

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond.
Marte, B M and Downward, J
Trends in Biochemical Sciences, 22, 355-358 (1997)
Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation
Belyanskaya, Larisa L, et al
International Journal of Cancer. Journal International Du Cancer, 117, 755-763 (2005)
Virginia Actis Dato et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 152, 113270-113270 (2022-06-17)
Antibodies against the P3 sequence (Gly1127-Cys1140) of LRP1 (anti-P3 Abs) specifically block cholesteryl ester (CE) accumulation in vascular cells. LRP1 is a key regulator of insulin receptor (InsR) trafficking in different cell types. The link between CE accumulation and the
Virginia Actis Dato et al.
Cells, 9(1) (2020-01-16)
Abstract: The cardiovascular disease (CVD) frequently developed during metabolic syndrome and type-2 diabetes mellitus is associated with increased levels of aggregation-prone small LDL particles. Aggregated LDL (aggLDL) internalization is mediated by low-density lipoprotein receptor-related protein-1 (LRP1) promoting intracellular cholesteryl ester
Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase.
Fu, XD; Goglia, L; Sanchez, AM; Flamini, M; Giretti, MS; Tosi, V; Genazzani, AR; Simoncini, T
Endocrine-Related Cancer null

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