07-841
Anti-phospho-IR/IGF1R (Tyr1158/Tyr1162/Tyr1163) Antibody
Upstate®, from rabbit
别名:
CD220, Insulin Receptor / CD221, Insulin-like Growth Factor 1 Receptor
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
mouse, human
Application:
western blot
Technique(s):
western blot: suitable
Citations:
6
Uniprot accession no.:
产品名称
Anti-phospho-IR/IGF1R (Tyr1158/Tyr1162/Tyr1163) Antibody, Upstate®, from rabbit
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pTyr1158/pTyr1162/pTyr1163)
Quality Level
Gene Information
human ... INSR(3643)
Analysis Note
Routinely evaluated by immunoblot.
Application
Anti-phospho-IR/IGF1R (Tyr1158/Tyr1162/Tyr1163) Antibody detects level of phospho-IR/IGF1R (Tyr1158/Tyr1162/Tyr1163) & has been published & validated for use in WB.
Immunoblot Analysis: 1:1000 dilutions of this lot detected phospho-IR (Tyr1158/Tyr1162/Tyr1163) in RIPA lysate of untreated and insulin treated CHO cells transfected with IR.
Research Category
Signaling
Signaling
Research Sub Category
Insulin/Energy Signaling
Insulin/Energy Signaling
Biochem/physiol Actions
Human and mouse phospho-Insulin Receptor (IR) Tyrosine 1158/1162/1163 and Insulin-like Growth Factor 1 Receptor (IGF1R) Tyr 1131/1135/1136. Rat reactivity is expected based on 100% sequence homology.
Predicted to cross-react with rat based on 100% sequence homology, but have not been tested.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
155 kDa
Immunogen
Peptide corresponding to the amino acid region encompassing the human, mouse, and rat phospho-Insulin Receptor (IR) Tyrosine 1158, 1162, and 1163 and Insulin-like Growth Factor 1 Receptor (IGF1R) Tyr 1131, 1135, and 1136.
Physical form
100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.
Affinity purified
Preparation Note
Stable for 2 years at -20°C from date of shipment.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Marina C Muñoz et al.
The Journal of endocrinology, 201(2), 185-197 (2009-03-03)
The I kappaB kinase-beta (IKK-beta)/nuclear factor-kappaB signaling pathway has been suggested to link inflammation with obesity and insulin resistance. In addition, angiotensin (Ang) II is able to induce insulin resistance and an inflammatory state through Ang II receptor type 1
R Chugh et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 26(7), 1459-1464 (2015-04-11)
Insulin-like growth factor receptor (IGF-1R) has been studied as an oncologic target in soft tissue sarcoma (STS), but its role in sarcoma biology is unclear. Anti-IGF-1R antibody cixutumumab demonstrated acceptable toxicity but limited activity as a single agent in STS.
Aaron Cooper et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(1), 56-66 (2010-11-05)
Ewing sarcoma family tumors (ESFT) are aggressive tumors of putative stem cell origin for which prognostic biomarkers and novel treatments are needed. In several human cancers, high expression of the polycomb protein BMI-1 is associated with poor outcome. We have
Marina C Muñoz et al.
Journal of molecular endocrinology, 69(2), 357-376 (2022-05-25)
Growth hormone (GH) exerts major actions in cardiac growth and metabolism. Considering the important role of insulin in the heart and the well-established anti-insulin effects of GH, cardiac insulin resistance may play a role in the cardiopathology observed in acromegalic
Hongyi Zhou et al.
JCI insight, 5 (2019-06-12)
Mutations in BSCL2 gene underlie human type 2 Berardinelli-Seip Congenital Lipodystrophy (BSCL2) disease. Global Bscl2-/- mice recapitulate human BSCL2 lipodystrophy and develop insulin resistance and hypertrophic cardiomyopathy. The pathological mechanisms underlying the development of lipodystrophy and cardiomyopathy in BSCL2 are
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