07-981
抗-Cbx7 抗体
from rabbit, purified by affinity chromatography
别名:
chromobox homolog 7, chromobox protein homolog 7
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunoprecipitation (IP)
western blot
western blot
Species reactivity:
mouse
Citations:
8
Technique(s):
immunoprecipitation (IP): suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-Cbx7 抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CBX7(23492)
Analysis Note
对照
小鼠胚胎干细胞裂解液
小鼠胚胎干细胞裂解液
通过蛋白质印迹在小鼠胚胎干细胞中进行评估。
蛋白质印迹分析：0.25 µg/mL的该抗体在10 µg小鼠胚胎干细胞裂解液中检测到Cbx7。
蛋白质印迹分析：0.25 µg/mL的该抗体在10 µg小鼠胚胎干细胞裂解液中检测到Cbx7。
Application
抗-Cbx7抗体是一种兔多克隆抗体，用于检测Chromobox蛋白同源物7（Cbx7），也称hromobox protein homolog 7 ，&已在WB& IP中得到验证。
研究子类别
染色质生物学
染色质生物学
研究类别
表观遗传学&核功能
表观遗传学&核功能
蛋白质印迹法（Snap i.d.）分析：2 µg/mL的代表性批次在10 µg人和小鼠胚胎干细胞裂解物中检测到 Cbx7。
免疫沉淀分析： 一个代表性批次已被独立实验室用于IP。
免疫沉淀分析： 一个代表性批次已被独立实验室用于IP。
Biochem/physiol Actions
该抗体识别Cbx7的C末端。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
Chromobox蛋白同源物7（Cbx7）是哺乳动物chromobox蛋白家族的成员。作为多梳抑制复合物1（PRC1）的成分，Cbx7涉及培养的上皮细胞寿命的维持和延长。研究表明，在已知肿瘤抑制位点INK4a/ARF的抑制中，它以独立于BMI-1的形式行使功能。 Cbx7 也可以通过维持CDKN2A抑制，调节细胞寿命。 研究表明Cbx7在滤泡性淋巴瘤中上调，说明它具有成为人类致癌基因的潜力。
观测值〜21 kDa。 在某些裂解物中可能观察到约44 kDa的非特异性条带。
Immunogen
GST标记的重组蛋白，对应于小鼠Cbx7的C末端。
表位：C端
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
亲和纯化
纯化的兔多克隆抗体，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Eleanor Glancy et al.
Molecular cell, 83(9), 1393-1411 (2023-04-09)
Polycomb repressive complex 2 (PRC2) mediates H3K27me3 deposition, which is thought to recruit canonical PRC1 (cPRC1) via chromodomain-containing CBX proteins to promote stable repression of developmental genes. PRC2 forms two major subcomplexes, PRC2.1 and PRC2.2, but their specific roles remain
Elizabeth S Jaensch et al.
Molecular cell, 81(22), 4677-4691 (2021-10-13)
The CBX family of proteins is central to proper mammalian development via key roles in Polycomb-mediated maintenance of repression. CBX proteins in differentiated lineages have chromatin compaction and phase separation activities that might contribute to maintaining repressed chromatin. The predominant
Junghyun L Suh et al.
Cell chemical biology, 29(4), 555-571 (2021-10-30)
Canonical targeting of Polycomb repressive complex 1 (PRC1) to repress developmental genes is mediated by cell-type-specific, paralogous chromobox (CBX) proteins (CBX2, 4, 6, 7, and 8). Based on their central role in silencing and their dysregulation associated with human disease
Jin He et al.
Nature cell biology, 15(4), 373-384 (2013-03-19)
Polycomb group (PcG) proteins play important roles in repressing lineage-specific genes and maintaining the undifferentiated state of mouse embryonic stem cells (mESCs). However, how PcG proteins are recruited to their target genes is largely unknown. Here, we show that the
Nadezda A Fursova et al.
Molecular cell, 74(5), 1020-1036 (2019-04-29)
The Polycomb system modifies chromatin and plays an essential role in repressing gene expression to control normal mammalian development. However, the components and mechanisms that define how Polycomb protein complexes achieve this remain enigmatic. Here, we use combinatorial genetic perturbation
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