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文件

COA分析证书/COQ

08-115

I型胶原，大鼠尾巴

Name: I型胶原，大鼠尾巴
Brand: MM

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eCl@ss:

32160405

NACRES:

NA.75

生物来源

rat

质量水平

100

形式

liquid

manufacturer/tradename

Upstate^®

technique(s)

cell culture | mammalian: suitable

input

sample type hematopoietic stem cell(s)
sample type mesenchymal stem cell(s)
sample type induced pluripotent stem cell(s)
sample type epithelial cells
sample type pancreatic stem cell(s)
sample type neural stem cell(s)
sample type: mouse embryonic stem cell(s)

NCBI登记号

NM_000088.3

UniProt登记号

P02452

运输

wet ice

储存温度

2-8°C

Gene Information

rat ... COL1A1(29393)

一般描述

在人类中，I型胶原蛋白是最丰富、表达最广泛的胶原蛋白。该异源三聚体包含两个α1（I）链和一个α2（I）链条。I型胶原α1（COL1A1）是I型胶原的主要成分，编码I型胶α1链前体。它具有重复的Gly-Xaa-Yaa三肽基序。胶原α-1（I）链蛋白是胶原复合物超家族的一员。COL1A1具有血管性血友病因子C型（vWFC）结构域、胶原三螺旋重复序列和原纤维胶原C末端结构域（COLF）。

应用

I型胶原蛋白，鼠尾可用于：

胶原蛋白3D增殖测定
终末期胶原增殖测定
在制备用于模板的微胶囊的比较研究中，在纯球霰石碳酸钙（CaCO3）晶体的介孔核上评估结构-性能关系
在盖玻片涂层中生长人脑微血管内皮细胞系（hCMEC/D3），用于创建细胞共培养和慢性硬膜下血肿（CSDH）患者血肿样品诱导的损伤模型

生化/生理作用

I型胶原 α1（COL1A1）在化疗耐药性中起着关键作用，并可能成为治疗靶点。参与卡铂耐药卵巢癌症（OV）。COL1A1在癌症（CRC）的发展中起着癌基因的作用。显性遗传COL1A1基因突变导致结缔组织疾病，如成骨不全症（OI）。

质量

通过测试对均匀凝胶化和对 PC-12 大鼠细胞的粘附和扩散进行了评估

外形

0.02N 醋酸，pH 3.67

储存及稳定性

4°C 下 1 年

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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索取COA

Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy.

Deron R Herr et al.

Scientific reports, 6, 24541-24541 (2016-04-16)

Ototoxic drugs, such as platinum-based chemotherapeutics, often lead to permanent hearing loss through apoptosis of neuroepithelial hair cells and afferent neurons of the cochlea. There is no approved therapy for preventing or reversing this process. Our previous studies identified a

Gelatinase A activation is regulated by the organization of the polymerized actin cytoskeleton.

J J Tomasek et al.

The Journal of biological chemistry, 272(11), 7482-7487 (1997-03-14)

Gelatinase A (GL-A) is a matrix metalloproteinase (MMP) involved in both connective tissue remodeling and tumor invasion. GL-A activation is mediated by a membrane-type MMP (MT-MMP) that cleaves the GL-A propeptide. In this study, we examined the role of the

Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion.

H Uyttendaele et al.

Developmental biology, 196(2), 204-217 (1998-05-13)

Elongation and branching of epithelial ducts is a crucial event during the development of the mammary gland. Branching morphogenesis of the mouse mammary epithelial TAC-2 cell line was used as an assay to examine the role of Wnt, HGF, TGF-beta

Reconstituted rattail collagen used as substrate for tissue cultures on coverslips in Maximow slides and roller tubes.

BORNSTEIN, M B

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Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3

Brooks, P. C., et al

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