Anti-ATF6 Antibody

ATF6 (Activating Transcription Factor 6, Cyclic AMP-dependent transcription factor ATF6) is a stress activated leucine zipper transcription factor involved in activating transcription of endoplasmic reticulum (ER) molecules in response to accumulation of unfolded proteins in the ER. ATF6 is originally a 90 kDa type II transmembrane glycoprotein that is converted to a 50 kDa soluble nuclear form, retaining its N-terminal domain, including the leucine zipper. Unfolded protein accumulation in the ER results in the cleavage of ATF6 to release its cytoplasmic domain that then enters the nucleus. ATF6 binds to an element designated ER Stress Response Element (ERSA) that appears in the promoter of glucose-regulated proteins (GRPs) such as GRP78, GPR94, and calreticulin.

KLH-tagged synthestic peptide synthesized to the N-terminal region of human ATF6 designated as the Cytoplasmic Domain.

Detect ATF6 using this Anti-ATF6 Antibody validated for use in WB.

Research Category
Signaling

Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

Routinely evaluated by western blot on HeLa lysate.

90 kDa

Affinity purified

Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide.

1 year at -20°C

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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