09-274
抗-PEAK1抗体
from rabbit, purified by affinity chromatography
别名:
NKF3 kinase family member, Sugen kinase 269
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PEAK1(79834)
General description
250kda
PEAK1属于蛋白激酶超家族。PEAK1也称酪氨酸蛋白激酶SgK269和Sugen激酶269。它包含一个分叉的、可能没有活性的真核蛋白激酶结构域。它有一个旁系同源物，也称SgK223或pragmin。 这两者构成了蛋白激酶NKF3亚家族，存在于脊椎动物和棘皮动物中。
Immunogen
表位：1511-1660 aa
重组蛋白，aa：1511-1660。同源性：100% 人和黑猩猩； 96% 猪和马；90%小鼠；88%大鼠
Application
该抗-PEAK1抗体经过验证可用于WB检测PEAK1。
Biochem/physiol Actions
其他物种尚未经过测试。
Analysis Note
对照
FG Nonstim /Nonstrvd 裂解液
FG Nonstim /Nonstrvd 裂解液
通过蛋白质印迹在FG Nonstim /Nonstrvd裂解液中进行了常规评估。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Exosome-delivered circSATB2 targets the miR-330-5p/PEAK1 axis to regulate proliferation, migration and invasion of lung cancer cells.
Zhu, et al.
Thoracic cancer, 13, 3007-3017 (2023)
Ken Fujimura et al.
Cancer research, 78(6), 1444-1456 (2018-01-13)
There remains intense interest in tractable approaches to target or silence the KRAS oncoprotein as a rational therapeutic strategy to attack pancreatic ductal adenocarcinoma (PDAC) and other cancers that overexpress it. Here we provide evidence that accumulation of the KRAS
Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma.
Aguilera, KY; Rivera, LB; Hur, H; Carbon, JG; Toombs, JE; Goldstein, CD; Dellinger et al.
Cancer Research null
Kristina Y Aguilera et al.
Molecular cancer therapeutics, 16(11), 2473-2485 (2017-09-03)
The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma (PDA), is rich in fibrillar collagens that facilitate tumor cell survival and chemoresistance. Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that specifically binds fibrillar collagens and
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