产品名称
抗-Dock2抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human, primate, horse
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DOCK2(1794)
Analysis Note
对照
小鼠脾脏裂解液
小鼠脾脏裂解液
通过蛋白质印迹对0.5 μg/mL抗DOCK2的小鼠脾脏裂解液进行了评估，浓度为1 mg/mL。
Application
免疫印迹法；抗Dock2抗体是一种针对Dock2的抗体，用于WBC
免疫组化（冰冻切片）：该抗体的代表性批次在小鼠和人脑冷冻组织切片中检测到DOCK2（Cimino, PJ et al. (2009).Am. J. Pathol.175(4); 1622-1630）
免疫组化（冰冻切片）：该抗体的代表性批次在小鼠和人脑冷冻组织切片中检测到DOCK2（Cimino, PJ et al. (2009).Am. J. Pathol.175(4); 1622-1630）
研究子类别
细胞骨架
细胞骨架
研究类别
细胞结构
细胞结构
Biochem/physiol Actions
09-454可识别小鼠DOCK2。
根据93%序列同源性，预测与人，马和灵长类动物发生交叉反应（13/14 aa）。该序列在大鼠中同源性为85.7%。与其他物种的反应性尚未得到测试。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
180 kDa
Dock2（胞质分裂2的专用蛋白）是参与细胞内信号网络的大蛋白，是DOCK-A亚家族的成员，其充当小G蛋白的激活剂。Dock2特异性激活小G蛋白Rac的亚型，并且似乎在白细胞中特异性表达。 这些细胞同时表达Rac1和Rac2，并且已显示Dock2结合并促进这两种亚型上的核苷酸交换。肽亲和纯化
Immunogen
小鼠DOCK2内部区域内氨基酸1730附近的KLH偶联合成肽。
表位：内部区域
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
在含有0.05%NaN3的PBS中纯化。
肽亲和纯化
Preparation Note
自收到之日起，在2-8°C下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Miho Ushijima et al.
Frontiers in immunology, 9, 243-243 (2018-03-06)
A hallmark of humoral immune responses is the production of antibodies. This process involves a complex cascade of molecular and cellular interactions, including recognition of specific antigen by the B cell receptor (BCR), which triggers activation of B cells and
Xia Guo et al.
Arteriosclerosis, thrombosis, and vascular biology, 43(6), e210-e217 (2023-04-07)
Abdominal aortic aneurysm (AAA) is a potentially lethal disease that lacks pharmacological treatment. Degradation of extracellular matrix proteins, especially elastin laminae, is the hallmark for AAA development. DOCK2 (dedicator of cytokinesis 2) has shown proinflammatory effects in several inflammatory diseases
Kazuhito Gotoh et al.
Blood, 111(6), 2973-2976 (2008-01-17)
The migratory properties of dendritic cells (DCs) are important for their functions. Although several chemokines and their receptors have been implicated in DC migration, the downstream signaling molecules are largely unknown. Here we show that DOCK2, a hematopoietic cell-specific CDM
Addendum: defective Dock2 expression in a subset of ASC-deficient mouse lines.
Sirish K Ippagunta,R K Subbarao Malireddi,Patrick J Shaw,Geoffrey A Neale et al.
Nature Immunology null
DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain.
Cimino, PJ; Sokal, I; Leverenz, J; Fukui, Y; Montine, TJ
The American Journal of Pathology null
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